老年初诊2型糖尿病病人血清淀粉样蛋白A、摄食抑制因子-1、25-羟维生素-D3水平变化及其与糖脂代谢、胰岛素抵抗的相关性  

Changes in serum amyloid A,ingestion inhibition factor-1,25-hydroxyvitamin-D3 levels in elderly patients with newly diagnosed type 2 diabetes mellitus and their correlation with glycolipid metabolism and insulin resistance

作　　者：陈曼丽[1] 范琳 石文焕 齐莉莉 郝咏梅 CHEN Manli;FAN Lin;SHI Wenhuan;QI Lili;HAO Yongmei(Department of Geriatrics,Shijiazhuang Third Hospital,Shijiazhuang,Hebei 050000,China;Department of Pathogenic Biology,School of Basic Medicine,Hebei Medical University,Shijiazhuang,Hebei 050000,China;Department of Endocrinology,The Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China)

机构地区：[1]石家庄市第三医院老年病科,河北石家庄050000 [2]河北医科大学基础医学院病原生物学教研室,河北石家庄050000 [3]河北医科大学第二医院内分泌科,河北石家庄050000

出　　处：《安徽医药》2021年第4期769-772,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨老年初诊2型糖尿病(T2DM)病人血清淀粉样蛋白A(SAA)、摄食抑制因子-1(Nesfatin-1)、25-羟维生素-D3[25(OH)D3)]水平变化及其与糖脂代谢、胰岛素抵抗的关系。方法选取2017年8月至2019年10月石家庄市第三医院老年初诊T2DM病人106例为T2DM组,按1∶1比例选取同期106例健康体检者为健康对照组。对比两组血清SAA、Nesfatin-1、25(OH)D3水平、血糖指标[餐后2 h血糖(2 h PG)、空腹血糖(FBG)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)]、胰岛素敏感性指数(ISI)、胰岛素抵抗指数(HOMA-IR)、餐后2 h胰岛素水平(2 h INS)水平,Pearson相关系数分析老年初诊T2DM病人血清SAA、Nesfatin-1、25(OH)D3水平与糖脂代谢、胰岛素抵抗的相关性。结果 T2DM组血清SAA(564.86±102.53)μg/L、Nesfatin-1(3.06±1.12)μg/L、2 h PG(17.49±3.67)mmol/L、FBG(9.64±2.52)mmol/L、2 h INS(40.29±4.57)mU/L、TC(5.83±1.49)mmol/L、TG(2.92±0.56)mmol/L水平高于健康对照组(496.28±94.42)μg/L、(1.04±0.47)μg/L、(9.58±2.46)mmol/L、(5.31±1.27)mmol/L、(35.63±3.47)mU/L、(4.68±1.26)mmol/L、(1.49±0.47)mmol/L,血清25(OH)D3水平(35.72±5.41)nmol/L低于健康对照组(50.69±6.42)nmol/L(P<0.05);T2DM组ISI(0.46±0.17)低于健康对照组(0.59±0.20),HOMA-IR(5.59±1.04)高于健康对照组(1.69±0.49)(P<0.05);T2DM病人血清SAA、Nesfatin-1水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈正相关,与血清ISI水平呈负相关,血清25(OH)D3水平与2 h PG、FBG、TC、TG、HOMA-IR水平呈负相关,与ISI水平呈正相关(P<0.05)。结论血清SAA、Nesfatin-1在老年初诊T2DM病人中呈高表达,血清25(OH)D3呈低表达,且表达与病人糖脂代谢、胰岛素抵抗关系密切,可作为病情程度评估因子。Objective To investigate the changes of serum amyloid A(SAA),ingestion inhibition factor-1(Nesfatin-1),25-hydroxyvitamin-D3 [25(OH)D3)] levels in elderly patients with newly diagnosed type 2 diabetes mellitus(T2DM) and their relationship with glycolipid metabolism and insulin resistance.Methods A hundred and six elderly patients newly diagnosed T2DM in Shijiazhuang Third Hospital from August 2017 to October 2019 were selected as T2DM group,and 106 healthy people receiving physical examination during the same period were selected as healthy control group according to the ratio of 1:1.The levels of serum SAA,Nesfatin-1,25(OH)D3 levels,the blood glucose indicators [2 h plasma glucose(2 h PG),fasting blood glucose(FBG)],blood lipid indicators[total cholesterol(TC),triacylglycerol(TG)],insulin sensitivity index(ISI),insulin resistance index(HOMA-IR) and 2 h postprandial insulin(2 h INS) were compared between the two groups.Pearson correlation coefficient was used to analyze the correlation between serum SAA,Nesfatin-1,25(OH)D3 levels and glycolipid metabolism and insulin resistance in elderly patients with newly diagnosed T2DM.Results Serum SAA(564.86±102.53) μg/L,Nesfatin-1(3.06±1.12) μig/L,2 h PG(17.49±3.67) mmol/L,FBG(9.64±2.52)mmol/L,2 h INS(40.29±4.57) mU/L,TC(5.83±1.49) mmol/L,and TG(2.92±0.56) mmol/L levels in the T2DM group were higher than those in the healthy control group [(496.28±94.42) μg/L,(1.04±0.47) μg/L,(9.58±2.46) mmol/L,(5.31±1.27) mmol/L,(35.63±3.47) mU/L,(4.68±1.26) mmol/L,(1.49±0.47) mmol/L],while the serum 25(OH)D3 level(35.72±5.41) nmol/L in the T2DM group was lower than that in the healthy control group(50.69±6.42) nmol/L(P<0.05).The ISI(0.46±0.17) of the T2DM group was lower than that of the healthy control group(0.59±0.20),while the HOMA-IR(5.59±1.04) was higher than that of the healthy control group(1.69±0.49)(P<0.05).Serum SAA and Nesfatin-1 levels in T2DM patients were positively correlated with 2 h PG,FBG,TC,TG,HOMA-IR levels,and negatively correlated with serum I

关 键 词：糖尿病 2型 淀粉样蛋白A 摄食抑制因子-1 25-羟维生素-D3 总胆固醇 胰岛素敏感性指数 老年人 

分 类 号：R587.1[医药卫生—内分泌]