股骨头坏死动物模型构建:如何更接近临床应用  

Constructing an animal model of femoral head necrosis:how to get closer to clinical application

作　　者：汤朔 侯德才[2] Tang Shuo;Hou Decai(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning Province,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning Province,China)

机构地区：[1]辽宁中医药大学,辽宁省沈阳市110847 [2]辽宁中医药大学附属医院,辽宁省沈阳市110032

出　　处：《中国组织工程研究》2021年第29期4691-4696,共6页Chinese Journal of Tissue Engineering Research

基　　金：沈阳市科技局科技人才应用技术研究计划项目(18014405),项目负责人:侯德才。

摘　　要：背景:股骨头坏死的病因和发病机制是医学者一直探讨的问题,至今为止没有明确答案。目的:追踪文献对股骨头坏死动物模型研究进展予以综述。方法:以“股骨头坏死;动物模型;Femoral head necrosis;Animal model”为中英文检索词,检索2011年至2020年知网数据库、维普数据库及万方数据库、PubMed等数据库的相关文献,对股骨头坏死动物模型建模方法的有关研究进行探讨。结果与结论:目前还没有一种动物模型完全符合人类股骨头坏死的病情发展变化。通过查阅文献了解到制备股骨头坏死模型的方法种类有很多,大致分为创伤性和非创伤性,创伤主要有物理损伤、化学损伤等;非创伤包括激素、激素联合脂多糖等。相比较其他而言,激素制备股骨头缺血性坏死动物模型具有创伤小,造模时间短等特点,对于研究更加合理。BACKGROUND:The etiology and pathogenesis of femoral head necrosis is a question that has been discussed by medical researchers,and there is no clear answer so far.OBJECTIVE:To review the research progress in animal models of femoral head necrosis.METHODS:Using the search terms of“femoral head necrosis;animal model,”CNKI,VIP,WanFang,and PubMed databases were searched for relevant articles about the modeling methods of animal models of femoral head necrosis published from 2011 to 2020.RESULTS AND CONCLUSION:Until now,there has been no animal model that is fully compatible with the development and changes of human femoral head necrosis.By literature retrieval,we found that there are various methods to prepare femoral head necrosis models,which can be roughly divided into traumatic and non-traumatic.Traumatic methods mainly include physical injury and chemical injury.Non-traumatic methods include hormones,hormones combined with lipopolysaccharides,etc.In comparison,hormones show less trauma and shorter modeling time in the preparation of a femoral head necrosis model,which is more reasonable for research.

关 键 词：股骨头坏死 动物模型 研究进展 创伤性 非创伤性 激素 综述 

分 类 号：R446[医药卫生—诊断学] R496[医药卫生—临床医学]