B淋巴细胞及相关细胞因子在骨免疫系统中对破骨细胞分化的作用  

Effect of B lymphocytes and related cytokines on osteoclast differentiation in the osteoimmunology system

作　　者：何易祥 赵宇昊 高昭 赵海燕[2] 王文己[2] He Yixiang;Zhao Yuhao;Gao Zhao;Zhao Haiyan;Wang Wenji(First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu Province,China;Department of Orthopedics,First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China)

机构地区：[1]兰州大学第一临床医学院,甘肃省兰州市730000 [2]兰州大学第一医院骨科,甘肃省兰州市730000

出　　处：《中国组织工程研究》2021年第29期4709-4714,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:作为免疫系统组成中重要的免疫细胞--B淋巴细胞可参与骨代谢过程的调控,对破骨细胞的分化发育发挥着重要的作用。目的:就B淋巴细胞的特征及其对破骨细胞分化过程产生的作用进行综述。方法:以关键词"骨免疫;B细胞;破骨细胞"在CNKI、万方等数据库中检索;以关键词"osteoimmunology;B lymphocyte;osteoclast"在PubMed、Web of Science等数据库中检索。检索自建库至2020年9月发表的相关文献,排除与主题不相关及重复性研究的文献,对最终纳入的58篇文献进行归纳分析。结果与结论:研究认为,体内的多种活性物质在调控免疫细胞分化的同时,也可对成骨细胞及破骨细胞产生调控作用。B细胞可能参与了骨破坏形成,并与疾病的活动度相关。B细胞通过维持RANKL/RANK/OPG通路中各因子的平衡,来维持骨代谢平衡。有多种物质可通过上调或下调B淋巴细胞诱导成熟蛋白1水平,参与破骨细胞的调控。B淋巴细胞可产生自身抗体参与破骨过程,也可通过非抗体依赖途径产生骨破坏效应。在人体内环境中,免疫系统和骨骼系统除了二者的关键细胞直接作用外,也可通过转录因子、细胞因子及相关受体等间接联系,并对二者的发育过程产生相互调节的作用。BACKGROUND:B lymphocytes,an important component of the immune system,participate in the regulation of bone metabolism,and play an important role in differentiation and development of osteoclasts.OBJECTIVE:To review the characteristics and effect of B lymphocytes during osteoclast differentiation.METHODS:We searched CNKI,WanFang,PubMed and Web of Science for relevant literatures published from their inceptions to September 2020.The keywords included“osteoimmunology;B lymphocyte;osteoclast”in Chinese and English,respectively.Irrelevant and repetitive literatures were excluded,and finally 58 articles were included for further review.RESULTS AND CONCLUSION:Studies have shown that a variety of active substances in the body are involved in both regulating the differentiation of immune cells and the generation of osteoblasts and osteoclasts.B lymphocytes may be involved in the formation of bone destruction and are related to the active stage of the disease.B lymphocytes can maintain the balance of bone metabolism by regulating RANKL/RANK/OPG pathway related cytokines.Various substances can regulate osteoclasts by up-regulating or down-regulating Blimp1 levels.B lymphocytes can produce autoantibodies to participate in the osteoclast process,but also produce bone destruction through non-antibody-dependent pathways.the immune and skeletal systems have mutual effects on their development through transcription factors,cytokines and related receptors.

关 键 词：骨免疫学 B淋巴细胞 破骨细胞 RANKL/RANK/OPG通路 结节性硬化症复合体1 B淋巴细胞诱导成熟蛋白1 

分 类 号：R459.9[医药卫生—治疗学] R496[医药卫生—临床医学]