脂蛋白酯酶在动脉粥样硬化发生发展中的作用  

Role of lipoprotein lipase in the development of atherosclerosis

作　　者：罗静静 王宗保 唐朝克[2] LUO Jingjing;WANG Zongbao;TANG Chaoke(School of Pharmaceutical Science,Hunan Collaborative Innovation Center of Molecular Target New Drug Research,University of South China,Hengyang 421001,China;Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学药学院,湖南省分子靶标新药研究协同创新中心,衡阳421001 [2]南华大学心血管疾病研究所,动脉硬化学湖南省重点实验室,动脉硬化性疾病湖南省国际科技合作创新基地,湖南省分子靶标新药研究协同创新中心,衡阳421001

出　　处：《生命的化学》2021年第1期19-24,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81770461)。

摘　　要：脂蛋白酯酶(lipoprotein lipase, LPL)是调节甘油三酯代谢的关键酶,在动脉粥样硬化(atherosclerosis,As)的发生发展中起重要作用。LPL产生部位的差异决定了其具有促As作用还是抗As作用。其次,不同因素对LPL的调控也会使LPL对As产生相反的作用效果。本文综述了LPL在As发生发展中的作用机制以及不同因素对LPL的调控机制,对于As的防治具有重要意义。Lipoprotein lipase(LPL) is a key enzyme that regulates triglyceride metabolism and plays an important role in the development of atherosclerosis(As). The difference of its producing position determines whether LPL has the effect of promoting As or suppressing As. In addition, the regulation of LPL by different factors will also cause the opposite effect of LPL on As. This review summarizes the specific mechanism of LPL on As and the regulation mechanism of different factors on LPL, which is of great significance for the prevention and treatment of As.

关 键 词：动脉粥样硬化 脂蛋白酯酶 甘油三酯 脂蛋白 

分 类 号：R543.5[医药卫生—心血管疾病]