一种新的细胞死亡形式——parthanatos研究进展  

Recent Progress in Parthanatos——a New Form of Cell Death

作　　者：杨希瑶 张娜 杨洋[1] 徐天瑞[1] 安输[1] YANG Xiyao;ZHANG Na;YANG Yang;XU Tianrui;An Shu(Key Laboratory of Target Drug Screening and Utilization of Yunnan Province,College of Life Sciences and Technology,Kunming University of Science and Technology,Kunming 650000,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南省高校靶点药物筛选与利用重点实验室,昆明650000

出　　处：《中国细胞生物学学报》2021年第1期39-46,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81760264、81960394);云南省基础研究计划重点项目(批准号:202001AS070024)资助的课题。

摘　　要：作为一种不同于凋亡的新型调控性细胞死亡形式,parthanatos与神经退行性疾病、中风、谷氨酸兴奋性中毒、活性氧(ROS)诱导的损伤和肿瘤等诸多疾病的发生发展密切相关。由于多聚ADP核糖聚合酶-1(ADP-ribose polymerase-1,PARP-1)的异常活化是诱发parthanatos发生的先决条件,所以parthanatos亦被称为PARP-1介导的细胞凋亡。此外,凋亡诱导因子(apoptosis inducing factor,AIF)和巨噬细胞迁移抑制因子(migration inhibitory factor,MIF)亦是parthanatos发生过程的关键因子。该文欲对parthanatos发生的分子机制及parthanatos对相关疾病发生发展影响的最新研究进展作一综述。As a new form of regulated cell death,parthanatos occurs by a mechanism different from apoptosis,and plays a key role in the pathological process of neurodegenerative diseases,stroke,glutamate-induced excitotoxicity,ROS(reactive oxygen species)-induced injury and tumors.Because the abnormal activation of PARP-1 is required for the induction of parthanatos,parthanatos is also known as PARP-1-mediated apoptosis.Additionally,AIF(apoptosis inducing factor)and MIF(macrophage migration inhibitory factor)are also the two key factors in the process of parthanatos.This review will describe the molecular mechanism of parthanatos and discuss its influence on the occurrence and development of some diseases.

关 键 词：parthanatos 凋亡诱导因子 多聚ADP核糖聚合酶-1 巨噬细胞迁移抑制因子 细胞凋亡 

分 类 号：Q255[生物学—细胞生物学]