运动对线粒体介导骨骼肌细胞凋亡信号通路的影响  

Effects of Exercise on the Signaling Pathway of Mitochondrial-Mediated Skeletal Muscle’s Apoptosis

作　　者：蔺海旗[1] 陈亮 王震[3] 林文弢[4] 元宇[4] LIN Haiqi;CHEN Liang;WANG Zhen;LIN Wentao;YUAN Yu(College of Physical Education,South China University of Technology,Guangzhou 510641,China;Institute of Physical Education and Health,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Guang Dong Youth Vocational College,Guangzhou 510545,China;School of Sports and Health,Guangzhou Sport University,Guangzhou 510500,China)

机构地区：[1]华南理工大学体育学院,广州510641 [2]广州中医药大学体育健康学院,广州510006 [3]广东青年职业学院,广州510545 [4]广州体育学院运动与健康学院,广州510500

出　　处：《中国细胞生物学学报》2021年第1期118-124,共7页Chinese Journal of Cell Biology

基　　金：教育部人文社会科学研究青年基金项目(批准号:20YJCZH090);广东省哲学社会科学“十三五”规划项目(批准号:GD19YTY01);广东省教育科学“十三五”规划项目(批准号:2018GXJK001);广东省攀登计划基金项目(批准号:PDJH2020a11092)资助的课题。

摘　　要：细胞凋亡是一种程序化的细胞死亡方式,其信号传导通路分为外源性和内源性两条主要途径,线粒体在内源性细胞凋亡途径中扮演着重要的角色。研究表明,运动可通过调节线粒体介导骨骼肌细胞凋亡的进程,而运动调节线粒体介导骨骼肌细胞凋亡信号通路影响机体细胞生物进程的机制仍有待研究。该文主要阐述了线粒体介导细胞凋亡信号传导通路及运动对其的调控作用机制,旨在为线粒体相关代谢性疾病的防治提供运动干预理论基础。Apoptosis is a programmed cell death.Its signal transduction pathway can be divided into exogenous and endogenous pathways.Mitochondria plays an important role in the intrinsic apoptotic pathway.It has been found that exercise can regulate the process of mitochondrial mediated apoptosis of skeletal muscle cells.However,the mechanism of motor regulation of mitochondria-mediated skeletal muscle cell apoptosis signaling pathway affecting the cellular biological processes has not been clarified.This article mainly elaborates the signal transduction pathway of mitochondria-mediated apoptosis and the mechanism of exercise regulating the signal transduction pathway,aiming to provide a theoretical basis for exercise intervention for the prevention and treatment of mitochondrial-related metabolic diseases.

关 键 词：运动 线粒体 骨骼肌 细胞凋亡 肌肉衰减症 

分 类 号：Q255[生物学—细胞生物学]