RNA结合蛋白与非编码RNA调节关系的研究进展  

Progress of Regulatory Relationships between RNA Binding Protein and Non-Coding RNA

作　　者：倪舒静 徐美倩 陈辰 王玲琳 朱婷琰 奕天飞 吉米丽古丽•艾尼 廖奇 NI Shujing;XU Meiqian;CHEN Chen;WANG Linglin;ZHU Tingyan;YI Tianfei;GIMILIGULI·Aini;LIAO Qi(Department of Preventative Medicine,Medicine School of Ningbo University,Ningbo 315211,China;Zhejiang Key Laboratory of Pathophysiology,Medicine School of Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学院,预防医学系,宁波315211 [2]宁波大学医学院,浙江省病理生理重点实验室,宁波315211

出　　处：《中国细胞生物学学报》2021年第1期263-272,共10页Chinese Journal of Cell Biology

基　　金：浙江省自然科学基金(批准号:LY21C060002);浙江省属高校基本科研业务费(批准号:SJLZ2021001);国家自然科学基金(批准号:31970630)资助的课题。

摘　　要：近年来,越来越多的研究表明,RNA结合蛋白(RNA binding protein,RBP)与多种类型的非编码RNAs(noncoding RNA,ncRNAs)具有互相调节的关系,且调节机制形式多样。一方面,RBP可以调节ncRNA的生物合成、稳定性和功能;另一方面,ncRNA也可以影响RBP的功能和结构。同时,RBP和ncRNA的相互作用还在其他靶基因的调节上起着重要的作用,从而参与众多的生物过程,如组织发育、代谢性疾病、神经退行性疾病、抗病毒免疫和各种癌症等。该文就RBP与常见类型的ncRNAs,包括miRNA、lncRNA、circRNA的相互作用方式和调节机制的研究进展作一综述。In recent years,more and more studies have shown that RBP(RNA binding protein)and various types of ncRNAs(noncoding RNAs)have mutual regulatory relationships.The interactions between RBP and ncRNA have diverse mechanisms.On one hand,RBP can regulate the biosynthesis,stability and function of ncRNA;on the other hand,ncRNA can also affect the function and structure of RBP.At the same time,the interaction between RBP and ncRNAs also plays an important role in the regulation of other target genes,therefore participating in many biological processes,such as tissue development,metabolic diseases,neurodegenerative diseases,antiviral immunity and various kinds of cancers.This review focuses on the research progress of the regulation mechanisms between RBP and several common kinds of ncRNAs,including miRNA,lncRNA,and circRNA.

关 键 词：RNA结合蛋白 非编码RNA 调节关系 MIRNA 长非编码RNA circRNA 

分 类 号：Q752[生物学—分子生物学]