铜绿假单胞菌胞质外功能σ因子研究进展  

Research Progress of Extracellular Function Sigma Factor in Pseudomonas aeruginosa

作　　者：蔡泽琼 陈学红 白芳[1] CAI Ze-qiong;CHEN Xue-hong;BAI Fang(College of Life Science,Nankai University,Tianjin 300071,China)

机构地区：[1]南开大学生命科学学院,天津300071

出　　处：《中国药学杂志》2021年第4期257-263,共7页Chinese Pharmaceutical Journal

基　　金：国家重点研发计划国际合作项目项目资助(2017YFE0125600)。

摘　　要：铜绿假单胞菌(Pseudomonas aeruginosa)是一种重要的人类条件致病菌,该菌具有多重耐药性,常在临床上引发难治性、反复性感染,是公认的抗感染治疗难点。铜绿假单胞菌在感染人类宿主的过程中,要不断调整自身的基因表达谱以适应宿主环境,这一适应性调控往往由胞质外功能(extracellular function, ECF)σ因子介导。对ECFσ因子的深入研究有助于揭示铜绿假单胞菌的感染机制和耐药机制。笔者对铜绿假单胞菌中ECFσ因子的结构、成员、功能、调控机制、研究方法这几方面进行综述,为铜绿假单胞菌ECFσ因子的研究提供理论借鉴。Pseudomonas aeruginosa is an important pathogenic bacteria of human. It is highly resistant to multiple antibiotics, often causes refractory and recurrent infectious diseases, and has been recognized as a treatment challenge in clinic. During infection, P. aeruginosa constantly adjusts its gene expression profile to adapt to the host environment, which is usually mediated by extracellular function(ECF) σ factor. An in-depth study of the ECF σ factor will help to reveal the mechanisms of infection and drug resistance of P. aeruginosa. In this paper, the structure, membership, function, regulatory mechanism and research methods of ECF σ factor in P. aeruginosa are reviewed, which provides a theoretical reference for study of ECF σ factor in P. aeruginosa.

关 键 词：铜绿假单胞菌 胞质外功能σ因子 反σ因子 

分 类 号：R969.1[医药卫生—药理学]