胃滞留浮筏给药系统研究进展  

Research Progress of Floating Raft Drug Delivery System for Gastric Retention

作　　者：孔艳 余璇 李娜 任晓亮[2] 王萌[1] KONG Yan;YU Xuan;LI Na;REN Xiao-liang;WANG Meng(State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,组分中药国家重点实验室,天津301617 [2]天津中医药大学中药学院,天津301617

出　　处：《中国药学杂志》2021年第4期264-269,共6页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金面上项目资助(81873191);天津市科技计划项目资助(20ZYJDJC00120)。

摘　　要：胃食管反流病是常见的胃肠道紊乱性疾病,近年来在我国的发病率有上升趋势。浮筏给药系统作为胃滞留给药系统之一,具有独特的非系统性机制、良好的组织相容性、促进搭载药物的持续释放、延长药物作用时间等优势,通过抑制胃内容物向食道反流来保护食管黏膜。笔者综述了近30年有关胃滞留浮筏给药系统的文章,并对此制剂系统的成型机制、影响因素、制剂性能表征、成筏聚合物类别等分别进行了总结,以期为相关领域的研究提供理论支持。Gastroesophageal reflux disease is a common gastrointestinal disorder, the incidence rate in China has an upward trend in recent years. As one of the gastric retention drug delivery systems, floating raft drug delivery system has a unique non-systematic mechanism, good histocompatibility, promoting the continuous release of loaded drugs, prolonging the time of drug action and other advantages, and protecting the esophageal mucosa by inhibiting gastric content to the esophagus reflux. In this paper, the articles about gastric floating raft delivery system in the past 30 years are reviewed, and the formation mechanism, influencing factors, performance characterization of the preparation system and raft polymer classification are summarized respectively, in order to provide theoretical support for related researches.

关 键 词：胃食管反流病 胃滞留给药系统 浮筏系统 

分 类 号：R944[医药卫生—药剂学]