尼可地尔联合前列地尔注射液治疗顽固性心绞痛患者的临床效果  

Clinical Effect of Refractory Angina Pectoris with Nikedil and Alprostadil Injection

作　　者：谢洪宇 XIE Hongyu(Department of Cardiology,Dandong Central Hospital,118002,China)

机构地区：[1]丹东市中心医院心内一科,辽宁丹东118002

出　　处：《中国医药指南》2021年第9期83-84,共2页Guide of China Medicine

摘　　要：目的探讨尼可地尔联合前列地尔注射液治疗顽固性心绞痛患者的临床效果。方法将2018年5月至2019年5月医院收治的68例顽固性心绞痛患者随机分为两组,各34例,对照组予以前列地尔注射液治疗,研究组予以尼可地尔联合前列地尔注射液治疗。治疗前后检测两组患者的血清C-反应蛋白(CRP)、白细胞介素6(IL-6)及同型半胱氨酸(HCY)水平以及血液流变学指标,并采用西雅图心绞痛量表(SAQ)对患者的预后效果进行评估。结果治疗后,研究组CRP、IL-6及HCY水平明显低于对照组,差异有统计学意义(P<0.05)。研究组血小板聚集率、血浆黏度、高切黏度、低切黏度明显优于对照组,差异有统计学意义(P<0.05)。研究组SAQ评分高于对照组,差异均有统计学意义(P<0.05)。结论采用尼可地尔联合前列地尔注射液治疗顽固性心绞痛可获得更好的效果,能够有效降低血清炎性因子水平,改善血液流变学指标。Objective To investigate the clinical effect of nikedil combined with prostol injection in the treatment of intractable angina pectoris.Methods The 68 patients with refractory angina pectoris admitted to the hospital from May 2018 to May 2019 were randomly divided into two groups,with 34 cases in each group.The control group received alprostadil injection,and the research group received nikedil combined with alprostadil injection.Serum levels of C-reactive protein(CRP),interleukin-6(IL-6),homocysteine(HCY)and hemorheology of the two groups were detected before and after treatment,and the patients were evaluated by the Seattle angina scale(SAQ).Results After treatment,the levels of CRP,IL-6 and Hcy in the research group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The platelet aggregation rate,plasma viscosity,high shear viscosity and low shear viscosity of the research group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).The SAQ score of the research group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment of intractable angina pectoris with nicodil combined with alprostadil injection can achieve better results,effectively reduce the level of serum inflammatory factors and improve the hemorheology.

关 键 词：顽固性心绞痛 尼可地尔 前列地尔 炎性因子 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病]