布地奈德结合氯雷他定联合治疗上呼吸道感染后咳嗽患者的效果  

Combination of Budesonide and Loratadine in the Treatment of Patients with Cough after Upper Respiratory Tract Infection

作　　者：宋秋红 SONG Qiuhong(Department of Respiratory and Critical Care Medicine,Northern Theater General Hospital,Shenyang 110000,China)

机构地区：[1]北部战区总医院呼吸与危重症医学科,辽宁沈阳110000

出　　处：《中国医药指南》2021年第8期1-3,共3页Guide of China Medicine

摘　　要：目的分析上呼吸道感染后咳嗽患者临床治疗中应用布地奈德结合氯雷他定的效果。方法以2015年1月至2019年12月86例上呼吸道感染后咳嗽患者为本研究对象,按照随机数字表法分为两组,对照组43例接受氯雷他定单药治疗,联合治疗组43例接受布地奈德结合氯雷他定治疗,比较两组临床疗效。结果联合治疗组治疗后咳嗽停止时间、咳痰停止时间、咽痒消除时间均短于对照组(P<0.05);联合治疗组治疗28 d后IFN-γ水平高于对照组,IL-4、TNF-α水平低于对照组(P<0.05);联合治疗组治疗期间药物不良反应发生率为11.63%,与对照组药物不良反应发生率13.95%差异无统计学意义(P>0.05);联合治疗组治疗的总有效率为93.02%,明显高于对照组的74.42%(P<0.05)。结论布地奈德、氯雷他定联合治疗上呼吸道感染后咳嗽患者可较单药治疗更迅速改善症状,更有效控制炎性因子水平,且不会影响治疗安全性。Objective To analyze the effect of budesonide combined with loratadine in clinical treatment of patients with cough after upper respiratory tract infection.Methods From January 2015 to December 2019,86 patients with cough after upper respiratory tract infection were taken as the research objects.They were divided into 2 groups according to the random number table method.The control group 43 received loratadine monotherapy and the combination treatment group 43 cases received budesonide combined with loratadine to compare the clinical efficacy.Results The time to stop coughing,the time to stop sputum and the elimination of pharyngeal itching after treatment in the combined treatment group were shorter than those in the control group(P<0.05);the IFN-γlevel of the combined treatment group was higher than that of the control group after 28 days of treatment.The level of TNF-αwas lower than that of the control group(P<0.05);the incidence of adverse drug reactions in the combined treatment group was 11.63%during the treatment period,and there was no significant difference in the incidence of adverse drug reactions in the control group(P>0.05).The total effective rate of treatment in the group was 93.02%,which was significantly higher than the total effective rate of 74.42%in the control group(P<0.05).Conclusion The combined treatment of budesonide and loratadine in patients with cough after upper respiratory tract infection can be more effective than monotherapy.Quickly improve symptoms,more effectively control the level of inflammatory factors,and will not affect the safety of treatment.

关 键 词：上呼吸道感染 咳嗽 布地奈德 氯雷他定 治疗 

分 类 号：R562[医药卫生—呼吸系统]