莫西沙星与左氧氟沙星治疗耐多药肺结核病的有效性和IFN-γ、IL-10分析  

Efficacy of Moxifloxacin and Levofloxacin in the Treatment of MDR-TB and Analysis of IFN-γ and IL-10

作　　者：吕月秋 LYU Yueqiu(Benxi Sixth People's Hospital,Benxi 117000,China)

机构地区：[1]本溪市第六人民医院,辽宁本溪117000

出　　处：《中国医药指南》2021年第8期38-39,共2页Guide of China Medicine

摘　　要：目的探究耐多药肺结核病患者接受莫西沙星与左氧氟沙星治疗的有效性以及对IFN-γ、IL-10水平的影响。方法将2018年1月至2019年4月100例耐多药肺结核病患者,以随机数字表法分组,对照组行左氧氟沙星治疗,试验组行莫西沙星治疗,分析两组耐多药肺结核病患者的治疗效果。结果治疗后两组患者IFN-γ水平较治疗前升高,IL-10水平较治疗前降低,且观察组改善程度显著优于对照组,P<0.05;试验组患者治疗总有效率(94.00%)高于对照组(78.00%),P<0.05;两组患者治疗后不良反应发生率差异无统计学意义(P>0.05)。结论耐多药肺结核病患者接受莫西沙星与左氧氟沙星治疗,均可获得一定的效果,但莫西沙星可更好促进患者细胞因子水平的改善,不良反应发生率低。Objective To explore the efficacy of moxifloxacin and levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis(MDRTB)and the influence on the levels of IFN-γand IL-10.Methods A total of 100 MDR-TB patients from January 2018 to April 2019 were divided into groups by random number table method.The control group was treated with levofloxacin,and the experimental group was treated with moxifloxacin.The treatment effect was analyzed in two groups of MDR-TB patients.Results After treatment,IFN-γlevel increased and IL-10 level decreased in both groups,and the degree of improvement in the experimental group was significantly better than that in the control group,P<0.05.The total effective rate of the experimental group(94.00%)was higher than that of the control group(78.00%),P<0.05.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Patients with MDR-TB treated with moxifloxacin versus levofloxacin can achieve some effect,but moxifloxacin can better promote the improvement of cytokine levels in patients,and the incidence of adverse effects is low.

关 键 词：耐多药肺结核病 莫西沙星 左氧氟沙星 IFN-Γ IL-10 

分 类 号：R521[医药卫生—内科学]