整合素αVβ3在糖尿病视网膜病变发生发展中的作用  

Role of integrin αVβ3 on occurrence and development of diabetic retinopathy

作　　者：萨如拉 闫朝丽[1] 任小燕[1] Sarula;Yan Zhaoli;Ren Xiaoyan(Department of Endocrinology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)

机构地区：[1]内蒙古医科大学附属医院内分泌科,呼和浩特010030

出　　处：《国际眼科纵览》2021年第1期51-56,共6页International Review of Ophthalmology

基　　金：内蒙古医科大学附属医院重大科技项目(NYFYZD001)。

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)作为长期高血糖诱导的进展性微血管病变,视网膜微血管的缺血、缺氧状态贯穿DR发病、进展的整个过程。整合素αVβ3(integrinαVβ3,ITGαVβ3)作为重要的细胞黏附分子,在高血糖状态下其自身及其配体表达均上调,并通过促进视网膜微血管通透性增加、新生血管形成及视网膜纤维膜形成等作用,参与到DR的各个病变阶段。由于ITGαVβ3通过多种机制参与DR,相较于目前广泛应用的抗血管内皮生长因子治疗,通过阻断ITGαVβ3与其配体的结合,能更加明显地改善视网膜微血管通透性、抑制视网膜新生血管形成。此外,ITGαVβ3配体所特含的RGD序列在靶向治疗DR方面有巨大潜力。Diabetic retinopathy(DR)is a progressive microangiopathy induced by long-term hyperglycemia.The state of ischemia and hypoxia of retinal microvessels runs through the whole process of the occurrence and progression of DR.IntegrinαVβ3(ITGαVβ3),as an important cell adhesion molecule,the expression of itself and its ligand upregulate in hyperglycemia,and participate in various pathological stages of DR by promoting retinal microvascular permeability,neovascularization and retinal fiber membrane formation.ITGαVβ3 participates in DR through a variety of mechanisms,compared with the widely used anti-VEGF therapy,blocking the binding of ITGαVβ3 to its ligand can significantly improve retinal microvascular permeability and inhibit retinal neovascularization.In addition,ITGαVβ3 ligand contains the RGD sequence,made it has great potential in targeted therapy of DR.

关 键 词：整合素ΑVΒ3 RGD序列 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]