紫外线致皮肤光老化及光癌变机制的研究进展  

Advances in research on ultraviolet-induced skin photoaging and photocarcinogenesis

作　　者：佘金铭 车静 陈聪颖 卢丽艳 赵洋 余瑞新 崔蕾[1] She Jinming;Che Jing;Chen Congying;Lu Liyan;Zhao Yang;Yu Ruixin;Cui Lei(Department of Medical Cosmetology,Yichang Central Peoples’s Hospital,the First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院医疗美容科,443003

出　　处：《中华整形外科杂志》2021年第2期220-224,共5页Chinese Journal of Plastic Surgery

摘　　要：日光的累计照射可加速皮肤老化与癌变,使皮肤的生物学及临床反应发生改变,包括急性损伤(日晒伤)和慢性损伤(光老化、光癌变或色素沉着等)。文章概述了近年来紫外线对皮肤光老化及光癌变影响的研究进展,揭示光老化和光致癌机制是通过紫外线照射产生活性氧和DNA损伤,以及由此引起的细胞损伤、炎症、免疫抑制、细胞外基质重塑及血管生成改变所致,为临床防治光老化和光癌变提供帮助。The cumulative exposure of sunlight can accelerate skin aging and canceration.It changes the biological and clinical reactions of the skin,including acute damage(sunburn)and chronic damage(photoaging,photocarcinogenesis,or pigmentation,etc.).This article summarizes the research progress in the effects of ultraviolet rays on skin photoaging and photocarcinogenesis in recent years.The mechanism of photoaging and photocarcinogenesis is the generation of ROS and DNA damage through ultraviolet irradiation,resulting cell damage,inflammation,immunosuppression,extracellular matrix remodeling and changes of angiogenesis.It provides help for the clinical prevention and treatment of photoaging and photocarcinogenesis.

关 键 词：皮肤衰老 紫外线 细胞外基质 活性氧 

分 类 号：R751[医药卫生—皮肤病学与性病学]