静脉注射用免疫球蛋白药学特点和临床应用探索  

Pharmaceutical Characteristics and Clinical Application of Intravenous Immunoglobulin

作　　者：宋钰 都丽萍[1] 屈静晗 梅丹[1] SONG Yu;DU Li-ping;QU Jing-han;MEI Dan(Department of Pharmacy.Peking Union Medical College Hospital,Peking U-nion Medical College&Chinese Academy of Medical Science,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院药剂科,北京100730

出　　处：《中国药学杂志》2021年第5期417-421,共5页Chinese Pharmaceutical Journal

摘　　要：目的探究静脉注射用免疫球蛋白的特点及临床应用,旨在为临床用药提供全面、有效的参考。方法通过以"静脉注射用免疫球蛋白""免疫球蛋白""IVIG""immunoglobulin"为关键词,检索CNKI、万方、PubMed、Embase、Web of Science等国内外多个数据库近十年发表的期刊文献和国内外最新临床治疗指南,汇总静脉注射用免疫球蛋白信息,着重介绍静脉注射用免疫球蛋白临床使用的证据支持。结果国内外静脉注射用免疫球蛋白制剂临床应用广泛,从作用机制、药动学特点、循证证据综合探究,对临床合理用药具有指导意义。结论未来需要结合临床需求开展真实世界研究或临床试验研究,获得更多循证证据的支持,保障IVIG临床合理使用,让更多患者获益。OBJECTIVE To investigate intravenous immunoglobulin development characteristics and clinical application,and to provide comprehensive and effective references for clinical medication.METHODS The information of intravenous immunoglobulin was collected by searching the journal literature of CNKI,Wanfang,PubMed,Embase,Web of Science,and other domestic and foreign databases,and the latest relevant clinical treatment guidelines at home and abroad,and the evidence-based evidence and safety of the clinical use of gamma globulin for intravenous injection were emphasized.RESULTS Gamma globulin preparations for intravenous injection at home and abroad are widely used in clinical practice.Comprehensive investigation from the perspective of mechanism of action,pharmacokinetic characteristics,evidence-based evidence,and safety has guiding significance for clinical medication.CONCLUSION In the future,carry out real-world research or clinical trial research should be carried out combined with clinical needs to obtain more evidence-based support,ensure the rational use of IVIG in clinical practice,and benefit more patients.

关 键 词：静脉注射用免疫球蛋白 作用机制 药动学 药学特点 临床应用 

分 类 号：R969.3[医药卫生—药理学]