卢秉久治疗重度非酒精性脂肪肝用药规律探论  

Discussion on LU Bingjiu’s Medication Rules for Severe Nonalcoholic Fatty Liver

作　　者：马玥 卢秉久[2] 郑佳连[2] MA Yue;LU Bingjiu;ZHENG Jialian(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2021年第1期48-51,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省科学技术基金(2019-MS-231)。

摘　　要：目的总结卢秉久教授治疗重度非酒精性脂肪肝的用药规律,分析卢秉久教授治疗重度脂肪肝的临床用药思路。方法收集2018年9月—2020年1月就诊于辽宁中医药大学附属医院感染科卢秉久教授治疗重度脂肪肝的患者的门诊病历,选取符合纳入标准的100例病历有效首诊处方,对其进行规范化处理,借助Microsoft Excel工作表、SPSS 23.0软件建立数据库,并对高频药物四气五味、归经、功效分类进行频率分析,相关性分析和聚类分析。结果频数分析显示,卢秉久教授治疗重度脂肪肝处方中共使用药物128味,累计1236频次,使用频率≥10%的高频药物有34种,累计961频次,占总频率77.8%。高频药物前10味分别是:陈皮、茯苓、泽泻、苍术、山楂、黄芪、白术、大腹皮、桂枝、车前子。卢秉久教授治疗重度脂肪肝过程中以利水渗湿药、补虚药为主;药物以温性为主,五味多为甘味,归经主归脾肝两经;相关性分析得出临床常使用药对为山楂-泽泻、桂枝-黄芪、红花-桃仁;聚类分析得出临床常使用的药物组,第一组为泽泻、决明子、红曲、山楂,第二组为陈皮、苍术、陈皮、大腹皮、桂枝、黄芪、白术、车前子。结论卢秉久教授治疗重度脂肪肝以健脾祛湿,化痰活血为主。Objective To summarize the medication rule of Professor LU Bingjiu in the treatment of severe non-alcoholic fatty liverandanalyze the clinical medication ideas of Professor LU Bingjiu in the treatment of severe fatty liver.Methods We collected outpatient medical records of patients with severe fatty liver treated by Professor LU Bingjiu in Department of Infectious Diseases of Affiliated Hospital of Liaoning University of Traditional Chinese Medicinefrom September 2018 to January 2020.A total of 100 effective medical prescriptions that met the inclusion criteria for the first diagnosis was selected to set up a database with the help of Microsoft Excel worksheets,SPSS 23.0 software.The frequency analysis,correlation analysis and cluster analysis of high-frequency drugs,four natures and five tastes,normalization and efficacy classification were carried out.Results Frequency analysis showed that Professor LU Bingjiu used a total of 128 drugs in the treatment of severe fatty liver prescriptions,with a total of 1236 frequencies.There were 34 high-frequency drugs with a frequency≥10%,with a total of 961 frequencies,accounting for 77.8%of the total frequency.The top tenhigh-frequency drugs were Chenpi(orange peel),Fuling(Poria),Zexie(Alisma),Cangzhu(Atractylodes),Shanzha(Hawthorn),Huangqi(Astragalus),Baizhu(Atractylodes),Dafupi(Atractylodes),Guizhi(cassia twig),Cheqianzi(Psyllium).During the treatment of severe fatty liver,Professor LU Bingjiu mainly used promoting urine and eliminating dampness drugs and tonifying drugs.The drugs were mainly warm,and the five tastes were mostly sweet.The common drug pairs were Shanzha(hawthorn)-Zexie(Alisma),Guizhi(cassia twig)-Huangqi(Astragalus),Honghua(safflower)-Taoren(peach kernel).Cluster analysis showedthe commonly-used drug group.The first group was Zexie(Alisma),Juemingzi(Cassia seed),Hongqu(red yeast),Shanzha(hawthorn).The second group was Chenpi(orange peel),Cangzhu(Atractylodes),Dafupi(Atractylodes),Guizhi(cassia twig),Huangqi(Astragalus),Baizhu(Atractylodes),Cheqianzi(psy

关 键 词：重度脂肪肝 卢秉久 用药规律 健脾祛湿 化痰活血 利水渗湿药 药对 药物组 

分 类 号：R259[医药卫生—中西医结合]