Dendron-polymer hybrid mediated anticancer drug delivery for suppression of mammary cancer  

作　　者：Dayi Pan Xiuli Zheng Miao Chen Qianfeng Zhang Zhiqian Li Zhenyu Duan Qiyong Gong Zhongwei Gu Hu Zhang Kui Luo 

机构地区：[1]Huaxi MR Research Center(HMRRC),Department of Radiology,Functional and Molecular Imaging Key Laboratory of Sichuan Province,National Clinical Research Center for Geriatrics,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,610041,China [2]Department of Orthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,Sichuan,China [3]Amegen Bioprocessing Centre,Keck Graduate Institute,CA,91711,USA

出　　处：《Journal of Materials Science & Technology》2021年第4期115-123,共9页材料科学技术（英文版）

基　　金：supported financially by National Natural Science Foundation of China(51673127,51873120,81621003,81801820);Department of Science and Technology of Sichuan Province(2018HH0006);Ministry of Science and Technology of the People’s Republic of China(2015DFE52780);China Postdoctoral Science Foundation(2018M643493);1·3·5 Research Funds in West China Hospital of Sichuan University(ZYGD18028);the Fundamental Research Funds for the Central Universities(2018SCU12032)。

摘　　要：Dendron-polymer-based nanoscale and stimuli-responsive drug delivery systems have shown great promise in tumor-targeting accumulation without significant toxicity.Here we report a dendronized polymer-doxorubicin(DOX)hybrid(DPDH)with an improved in vivo drug delivery efficiency for cancer therapy compared with a linear polymer-DOX conjugate(LPDC).The in vitro drug release profile of DOX indicates that DPDH displays pH-responsive drug release due to cleavage of hydrazone bonds since a greater amount of DOX is released at pH 5.2 at a faster rate than at pH 7.4.DPDH efficiently enters 4 T1 cells and releases DOX to induce cytotoxicity and apoptosis.Owing to the dendronzied structure,DPDH has a significantly longer blood circulation time than LPDC.DPDH substantially enhances the therapeutic efficacy to suppress tumor growth in a 4 T1 mammary cancer model than LPDC as well as free drug,evidenced from tumor growth inhibition,TUNEL assessment and histological analysis.Biosafety of DPDH is also confirmed from hemolysis,body weight shifts during treatment and pathological analysis.This study demonstrates the use of dendronized polymer-DOX hybrids for specific drug molecules is a promising approach for drug delivery.

关 键 词：cancer analysis. RELEASE 

分 类 号：TQ317[化学工程—高聚物工业] TQ460.4