长链非编码RNA在脑缺血发病机制中的作用研究进展  

Progress in search for the role of long non-coding RNA in cerebral ischemia

作　　者：彭拥军[1] 徐疏影 吕鹤群 李文倩 吴旭[1] 朱冰梅 PENG Yong-jun;XU Shu-ying;LV He-qun;LI Wen-qian;WU Xu;ZHU Bing-mei(Department of Acupuncture and Rehabilitation of Jiangsu Privince Hospital of Chinese Medicine,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Department of Acupuncture of Hospital of Traditional Chinese Medicine of Yancheng,Yancheng 224001,Jiangsu Province,China;Centre for Regenerative Medicine of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]江苏省中医院针灸康复科南京中医药大学附属医院,江苏南京210029 [2]盐城市中医院,江苏盐城224001 [3]四川大学华西医院,四川成都610041

出　　处：《中国临床药理学杂志》2021年第5期590-595,共6页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81973932,81574060,81001556);中国博士后科学基金资助项目(2015M571790);第六批全国老中医药专家学术经验继承人项目基金资助项目(国中医药人教发[2017]29号)。

摘　　要：长链非编码RNA(LncRNA)是一种缺乏完整开放阅读框的非编码RNA,在细胞增殖、分化和凋亡等生物学过程中发挥重要作用。其可通过表观遗传修饰、选择性剪接、转录后调控和翻译调控等多种机制参与调控蛋白编码和表观遗传基因。大量研究显示,LncRNA在神经功能性疾病中表达异常。本文就LncRNA在脑缺血中的机制研究进展做一系统综述。Long non-coding RNA(LncRNA)is a kind of non-coding RNA lacking a complete open reading frame.It plays an important role in the biological processes of cell proliferation,differentiation and apoptosis.It can be involved in the regulation of protein coding and epigenetic genes through epigenetic modification,selective splicing,post-transcriptional regulation and translational regulation.A large number of studies have shown the abnormal expression of LncRNA in neurofunctional diseases.This paper reviews the mechanism of LncRNA in cerebral ischemia.

关 键 词：长链非编码RNA 脑缺血 细胞凋亡 血管新生 自噬 

分 类 号：R97[医药卫生—药品]