新生儿病理性黄疸应用枯草杆菌二联活菌辅助治疗的疗效及安全性研究  

Study on the Efficacy and Safety of Adjuvant Treatment of Neonatal Pathological Jaundice with Bacillus Subtilis Dual Live Bacteria

作　　者：黄晓明 HUANG Xiao-ming(Department of Pediatrics,Quanzhou Guangqian Hospital,Quanzhou,Fujian Province,362321 China)

机构地区：[1]泉州市光前医院儿科,福建泉州362321

出　　处：《中外医疗》2020年第36期95-97,共3页China & Foreign Medical Treatment

摘　　要：目的探讨新生儿病理性黄疸应用枯草杆菌二联活菌辅助治疗的疗效及安全性研究,为临床提供参考依据。方法方便选择2018年11月—2020年3月在该院进行治疗的新生儿病理性黄疸患者106例为研究对象。按照随机数字表法,将患者分为对照组与研究组,每组53例。对照组患儿使用茵栀黄口服液进行治疗,研究组患儿在对照组的基础上使用枯草杆菌二联活菌进行辅助治疗。6 d后,比较分析两组患儿临床疗效、药物起效时间、治疗时间、治疗前后总胆红素水平、总胆红素水平日均下降值以及并发症发生状况。结果治疗后,研究组总有效率(96.23%)明显高于对照组(84.91%),差异有统计学意义(χ^(2)=6.316,P=0.009);研究组药物起效时间与治疗时间明显短于对照组,差异有统计学意义(t=8.462,P=0.001;t=6.428,P=0.011);研究组总胆红素水平明显低于对照组[(74.26±11.39)μmol/L vs(96.48±13.73)μmol/L],差异有统计学意义(t=8.849,P=0.001),且研究组总胆红素水平日均下降值明显高于对照组[(34.84±4.12)μmol/L vs(27.53±3.15)μmol/L],差异有统计学意义(t=5.394,P=0.025);在治疗过程中,所有患儿都没有出现同药物有关的不良反应。结论新生儿病理性黄疸应用枯草杆菌二联活菌进行辅助治疗疗效好、起效快、治疗时间短,且安全性较高。Objective To investigate the efficacy and safety of Bacillus subtilis dual live bacteria adjuvant therapy for neonatal pathological jaundice,and to provide clinical reference.Methods A total of 106 neonatal pathological jaundice patients who were treated in the hospital from November 2018 to March 2020 were conveniently selected as the research objects.According to the random number table method,the patients were divided into a control group and a study group,with 53 cases in each group.The patients in the control group were treated with Yinzhihuang Oral Liquid,and the patients in the study group were treated with double live bacillus subtilis on the basis of the control group.After 6 days,the clinical efficacy,drug onset time,treatment time,total bilirubin level before and after treatment,daily decline in total bilirubin level,and complications of the two groups were compared and analyzed.Results After treatment,the total effective rate of the study group(96.23%)was significantly higher than that of the control group(84.91%),the difference was statistically significant(χ^(2)=6.316,P=0.009);the drug onset time and treatment time of the study group were significantly shorter In the control group,and the difference was statistically significant(t=8.462,P=0.001;t=6.428,P=0.011);the total bilirubin level of the study group was significantly lower than that of the control group(74.26±11.39)μmol/L vs(96.48±13.73)μmol/L,and the difference was statistically significant(t=8.849,P=0.001),and the average daily decrease of total bilirubin level in the study group was significantly higher than that in the control group(34.84±4.12)μmol/L vs(27.53±3.15)μmol/L,and the difference was statistically significant(t=5.394,P=0.025);during the treatment,all patients had no drug-related Adverse reactions.Conclusion The adjuvant treatment of neonatal pathological jaundice with Bacillus subtilis dual live bacteria has good effect,fast onset,short treatment time,and high safety.

关 键 词：病理性黄疸 新生儿 枯草杆菌二联活菌 安全性 疗效 

分 类 号：R4[医药卫生—临床医学]