小胶质细胞极化在脊髓损伤中的作用与机制研究进展  

Role and mechanism of microglia polarization on spinal cord injury

作　　者：武作龙 达朝明 赵光海[1] 马麟 刘开鑫 向高 巩朝阳 张海鸿[1] Wu Zuolong;Da Chaoming;Zhao Guanghai;Ma Lin;Liu Kaixin;Xiang Gao;Gong Chaoyang;Zhang Haihong(Department of Orthopedics,The Second Hospital of Lanzhou University,Key Laboratory of Bone and Joint Disease Research of Gansu Province)

机构地区：[1]兰州大学第二医院骨科、甘肃省骨关节疾病研究重点实验室,兰州730000

出　　处：《重庆医科大学学报》2021年第3期268-272,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:31960175);甘肃省自然科学基金青年科技基金计划资助项目(编号:18JR3RA331)。

摘　　要：脊髓损伤(spinal cord injury,SCI)是一种常见的难治性疾病,一直是临床研究热点。它不仅损害患者的身心健康,也给家庭及社会带来沉重的经济负担。虽然对SCI的研究有很多,然而迄今为止对SCI的确切机制仍不清楚,因此缺乏有效的治疗手段。近年的相关研究表明,小胶质细胞极化后引起的炎症反应在SCI中扮演重要角色。本文就小胶质细胞极化在SCI中的作用与机制进行综述,希望能为SCI治疗提供新的策略。Spinal cord injury(SCI)is a common refractory disease and has been a focus of clinical research. It not only damages patients’ physical and mental health,but also brings a heavy financial burden to their family and society. Although there are many researches on SCI,its exact mechanism still remains unclear. Therefore,effective treatments for SCI are in urgent needs. In recent years,relevant studies have shown that the inflammatory reaction caused by microglia polarization plays an important role in SCI. Therefore,this paper reviews the mechanism of microglia polarization in SCI,so as to provide new therapeutic strategies for SCI in the future.

关 键 词：小胶质细胞 极化 脊髓损伤 炎症反应 信号通路 

分 类 号：R816.8[医药卫生—放射医学]