阿托伐他汀治疗稳定型冠心病的临床效果观察  

Clinical effect of atorvastatin in the treatment of stable coronary heart disease

作　　者：谢洪宇 XIE Hong-yu(Dandong Central Hospital,Dandong 118002,China)

机构地区：[1]辽宁省丹东市中心医院,118002

出　　处：《中国实用医药》2021年第9期88-90,共3页China Practical Medicine

摘　　要：目的对阿托伐他汀治疗稳定型冠心病的临床效果进行分析。方法120例稳定型冠心病患者,随机分为对照组和观察组,每组60例。对照组患者采用常规治疗,观察组患者在对照组基础上联合阿托伐他汀治疗。比较两组患者治疗前后血脂指标水平、缺血事件发生情况。结果治疗前,两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较差异无统计学意义(P>0.05);治疗后,观察组患者TC(4.27±0.42)mmol/L、TG(2.14±0.59)mmol/L、LDL-C(0.93±0.52)mmol/L均低于对照组的(5.43±0.94)、(2.44±0.71)、(3.27±0.34)mmol/L,HDL-C(1.44±0.54)mmol/L高于对照组的(1.24±0.44)mmol/L,差异具有统计学意义(P<0.05)。观察组患者缺血事件发生率为5.0%,低于对照组的16.7%,差异具有统计学意义(P<0.05)。结论采用阿托伐他汀治疗稳定型冠心病有助于改善患者血脂指标,降低缺血事件发生率,为稳定型冠心病的临床治疗提供了参考依据。Objective To analyze the clinical effect of atorvastatin in the treatment of stable coronary heart disease.Methods A total of 120 patients with stable coronary heart disease were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with atorvastatin based on the control group.The blood lipid indexes before and after treatment and occurrence of ischemic events were compared between the two groups.Results Before treatment,there was no statistically significant difference in total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)between the two groups(P>0.05).After treatment,the TC(4.27±0.42)mmol/L,TG(2.14±0.59)mmol/L and LDL-C(0.93±0.52)mmol/L of the observation group were lower than(5.43±0.94),(2.44±0.71)and(3.27±0.34)mmol/L of the control group,and HDL-C(1.44±0.54)mmol/L was higher than(1.24±0.44)mmol/L of the control group.All the difference was statistically significant(P<0.05).The incidence of ischemic events of the observation group was 5.0%,which was significantly lower than 16.7%of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of stable coronary heart disease,atorvastatin is helpful to improve blood lipid indexes and reduce the incidence of ischemic events,which provides a reference for the clinical treatment of stable coronary heart disease.

关 键 词：稳定型冠心病 阿托伐他汀 缺血事件 效果 

分 类 号：R541.4[医药卫生—心血管疾病]