低共熔溶剂中对硝基苯甲酸乙酯的绿色合成  

GREEN SYNTHESIS OF ETHYL p-NITROBENZOATE IN DEEP EUTECTIC SOLVENT

作　　者：王英磊[1] 李文欢 赵天舒 李默 Wang Yinglei;Li Wenhuan;Zhao Tianshu;Li Mo(School of Biological and Chemical Engineering,Nanyang Institute of Technology,Nanyang 473004,He’nan,China)

机构地区：[1]南阳理工学院生物与化学工程学院,河南南阳473004

出　　处：《精细石油化工》2021年第2期30-33,共4页Speciality Petrochemicals

基　　金：河南省科技攻关项目(182102310601)。

摘　　要：以低共熔溶剂氯化胆碱-对甲苯磺酸为催化剂,以对硝基苯甲酸和乙醇为原料,合成对硝基苯甲酸乙酯,考察了低共熔溶剂用量、反应物配比、回流时间等因素对产物收率的影响。较佳工艺条件为:氯化胆碱-对甲苯磺酸用量1.5 g,对硝基苯甲酸与乙醇摩尔比1∶6,回流时间2.0 h,此条件下对硝基苯甲酸乙酯的收率可达95%。此外,低共熔溶剂可回收和重复使用5次,酯化产物的收率没有显著下降。The ethyl p-nitrobenzoate was synthesized with p-nitrobenzoic acid and ethanol as starting materials,choline chloride-p-toluene sulfonic acid as catalyst.The influences of deep eutectic solvent dosage,reactants ratio and reflux time on the yield of the product were discussed.The yield of ethyl p-nitrobenzoate could reach 95%,under the optimum reaction conditions with amount of choline chloride-p-toluene sulfonic acid 1.5 g,molar ratio of p-nitrobenzoic acid to ethanol 1∶6 and reflux time 2.0 h.Moreover,the deep eutectic solvent could be recovered and reused for five times,and the yield of esterification product was not decreased significantly.

关 键 词：对硝基苯甲酸乙酯 低共熔溶剂 绿色化学 酯化反应 

分 类 号：O625.5[理学—有机化学]