尼可地尔对不稳定型心绞痛患者PCI术后心绞痛的疗效观察  

Curative effect of Nicorandil on angina pectoris in patients with unstable angina after PCI

作　　者：邓荣花 冯碧阳 Deng Ronghua;Feng Biyang(The Fifth People's HospitalofDatong City,DatongShanxi 037000;The Shanxi Datong University,Datong Shanxi037000)

机构地区：[1]大同市第五人民医院,山西大同037000 [2]山西大同大学,山西大同037000

出　　处：《基层医学论坛》2021年第10期1362-1365,共4页The Medical Forum

摘　　要：目的观察尼可地尔对不稳定型心绞痛患者经皮冠状动脉成形术(PCI)术后心绞痛的临床效果。方法选取不稳定型心绞痛行PCI治疗患者90例,随机分为对照组及观察组,每组45例。2组均给予冠心病二级预防,对照组口服单硝酸异山梨酯缓释片,观察组口服尼可地尔,记录2组患者的心绞痛发作次数、心电图测定结果,评价2组心绞痛疗效及心电图疗效,比较治疗前后肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-a)水平,记录治疗期间不良反应情况。结果治疗后观察组心绞痛总有效率84.4%,明显高于对照组的55.6%,差异有统计学意义(P<0.05)。观察组治疗后心电图总有效率为82.2%,明显高于对照组的53.4%,差异有统计学意义(P<0.05)。2组CK-MB、cTnI、IL-6、TNF-a治疗后较治疗前均显著降低,且观察组较对照组低,差异有统计学意义(P<0.05)。治疗期间2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论尼可地尔可降低不稳定型心绞痛患者PCI术后炎性因子,缓解心绞痛症状,减少心肌损伤,安全性好。Objective To observe the Curative effect of nicorandil on angina pectoris in patients with unstable angina after PCI.Methods Ninety patients with unstable angina after PCI were randomly divided intoControl group and the observation group,with 45 cases in each group.On the basis of class 2 preventive treatment,the control group was treated with oral mononitrate and isosorbide mononitrate sustained release tablets,and the observation group was gived nicorandil,The attack times,and outcomes of electrocardiogram(ECG)of were recorded in all patients.Evaluated the curative effect of angina pectoris and ECG.The levels of CK-MB,CTnI,IL-6 and TNF-a were compared between the two groups before and after treatment.Recorded the adverse reactions during treatment.Results After treatment,the total effective rate of nicorandil for angina pectoris in the observation group was significantly higher than those in the control group,and the difference was statistically significant(84.4%vs 55.6%,P<0.05).After treatment,the total effective rate of nicorandil for outcomes of ECG in the observation group was significantly higher than those in the control group,and the difference was statistically significant(82.2%vs 53.4%,P<0.05).After treatment,the levels of CK-MB,cTnI,IL-6 and TNF-a in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the changes of CK-MB,cTnI,IL-6 and TNF-a in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Nicorandil can reduce inflammatory factors in patients with unstable angina pectoris after PCI,relieve angina symptoms,reduce myocardial damage,and has good safety.

关 键 词：不稳定型心绞痛 经皮冠状动脉成形术 尼可地尔 术后心绞痛 

分 类 号：R4[医药卫生—临床医学]