一项单中心十年的血管炎住院病种流行病学资料分析  

A ten-year monocenter epidemiological analysis of the subtypes of hospitalized patients with vasculitis

作　　者：陈荣毅 吴思凡 俞文溯 孙颖 纪宗斐[1,2] 崔晓萌 孔秀芳[1,2] 马莉莉 姜林娣[1,2] CHEN Rong-yi;WU Si-fan;YU Wen-su;SUN Ying;JI Zong-fei;CUI Xiao-meng;KONG Xiu-fang;MA Li-li;JIANG Lin-di(Department of Rheumatology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Center for Evidence-based Medicine,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院风湿科,上海200032 [2]复旦大学循证医学中心,上海200032

出　　处：《复旦学报（医学版）》2021年第2期162-168,228,共8页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81801598,81771730,81901639)。

摘　　要：目的描述单中心血管炎住院患者的分布及临床特征。方法本横断面研究收集2009年1月1日至2019年1月1日在复旦大学附属中山医院住院的诊断为血管炎的患者,分析其血管炎分型,比较不同亚型血管炎患者的分布特点。结果共纳入血管炎住院患者1780例(12.7%),其中女性957例(53.8%),中位年龄为48岁(四分位间距:34~62岁)。以大动脉炎(646例,4.6%)、抗中性粒细胞胞质抗体(antineutrophil cytoplasmic antibody,ANCA)相关性血管炎(475例,3.4%)、IgA血管炎(250例,1.8%)和血栓闭塞性血管炎(154例,1.1%)为主,这4类患者主要就诊于风湿科、肾内科、肾内科和血管外科,总体重复住院率为48.3%。血管炎患者主要来自于江苏省、上海市、浙江省和安徽省。高血压、糖尿病和肾脏病是血管炎最常见的合并症。结论本院住院患者血管炎以大血管炎、ANCA相关性血管炎、IgA血管炎和血栓闭塞性血管炎为主,患者疾病负担较重。患者主要来源于本市及周边地区,常就诊于风湿免疫科,高血压是血管炎最常见的合并症,在其防治中应予以更多关注。Objective To describe the distribution and characteristics of the vasculitis subtypes in monocenter hospitalized patients.Methods Patients with vasculitis who were hospitalized in Zhongshan Hospital,Fudan University from Jan 12009 to Jan 12019 were enrolled in the present cross-sectional study.Patients were divided into different subgroups and compared subsequently according to the vasculitis subtypes.Results A total of 1780 patients were included in the present study,among which 957 cases(53.8%)were female,with a median age of 48.0(interquartile range:34.0-62.0)years.Takayasu’s arteritis(TA),antineutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV),IgA vasculitis(IgAV),and thrombosis angiitis obliterans(TAO)constitute the four main parts with the percent of 4.6%,3.4%,1.8%and 1.1%,respectively.These four types of vasculitis patients mainly derived from the department of rheumatology,nephrology,nephrology,and vascular surgery,and the overall readmission rate was 48.3%.Most of the vasculitis patients derived from Shanghai city,Jiangsu,Zhejiang and Anhui province.The hypertension,diabetes mellitus and kidney lesion were the most common comorbidity for vasculitis.Conclusions The vasculitis patients hospitalized in our hospital were mainly TA,AAV,IgAV and TAO.Patients mainly derived from Shanghai and the neighboring provinces.Hypertension was the most common comorbidity,which deserves further attention for a better prognosis.

关 键 词：血管炎 分型 流行病学 合并症 

分 类 号：R593[医药卫生—内科学]