Fib-4指数在非纤维化分期中的研究进展  

Research progress about Fib4 in non-fibrotic staging

作　　者：李玲[1] 陈玉兰[2] 陈帅 王晨霞[4] LI Ling;CHEN Yulan;CHEN Shuai(Yan’an University Master’s Degree 2018,Shaanxi,Yan’an 716000,China;不详)

机构地区：[1]延安大学,陕西省延安市716000 [2]陕西省延安市人民医院产科 [3]陕西省富县人民医院神经外科 [4]延安大学附属医院东关分院心血管内科,陕西省延安市716000

出　　处：《河北医药》2021年第5期766-770,共5页Hebei Medical Journal

摘　　要：Fib-4指数是一种无创、简单、快速、低成本的检测方法,用来评估肝纤维化分级,该指数将天冬氨酸氨基转移酶(AST)水平,丙氨酸氨基转移酶(ALT)水平、血小板计数和年龄结合在一起,最初用于丙型肝炎病毒(HCV)合并艾滋病病毒(HIV)患者的肝纤维化分期,在此之后被用于量化各种肝病的纤维化分级,包括HCV或乙型肝炎病毒感染(HBV),酒精性肝病和非酒精性脂肪肝(NAFLD)。与其他非侵入性纤维化标记物相比,具有较高的敏感性和特异性,因此广泛应用于评估肝纤维化程度。因此,本文就Fib-4指数在除评估肝纤维化分级以外的其他领域中的研究进行综述,以期推广在临床中的应用。The detection of Fibrosis-4(Fib-4)index is an non-invasive,simple,rapid,and low-cost method in diagnosing liver fibrosis grades,which is initially used for the staging of liver fibrosis in patients with the infection of hepatitis C virus(HCV)combined with HIV(HIV),combining with the detection of the levels of aspartate aminotransferase(AST),alanine aminotransfer-ase(ALT),platelets count as well as patient’s age.After that,which has been used to quantify the fibrosis grades of various liver diseases,including HCV or hepatitis B virus infection(HBV),alcoholic liver disease and non-alcoholic fatty liver(NAFLD).As compared with the other non-invasive fibrosis markers,which has higher sensitivity and specificity,so it is widely used to predict the severity of liver fibrosis.However,at present,there is few research about Fib-4 index in predicting the prognosis of patients with liver cancer after operation,in predicting the curative effects of antiviral drugs and adverse reactions,and its relationship with heart and kidney and other diseases.Therefore,this article reviews the researches about Fib-4 index in the other fields,in order to promote its clinical application.

关 键 词：Fib-4指数 肝癌 抗病毒药物 心肾疾病 

分 类 号：R195[医药卫生—卫生统计学]