快速康复外科学护理联合延续性护理对胆囊癌患者预后及CA125蛋白、miR-196a的影响  

Effects of rapid rehabilitation surgical nursing on CA125 protein,miR-196a and the prognosis of patients with gallbladder cancer

作　　者：张鹏娟[1] 崔大鹏[1] 张星月 宋文丽[1] 张迎春[1] 刘振显[1] 连晶晶[1] 刘博[1] ZHANG Pengjuan;CUI Dapeng;ZHANG Xingyue(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Hebei North College,Hebei,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院肝胆外科,河北省张家口市075000

出　　处：《河北医药》2021年第5期784-787,共4页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划(编号:20190915)。

摘　　要：目的探讨快速康复外科学护理联合延续性护理对胆囊癌患者预后及糖类抗原125(CA125)、微小RNA-196(miR-196a)的影响。方法选取2018年1月至2019年1月收治的62例胆囊癌患者,按照随机数字表法分为观察组和对照组,每组31例。对照组患者采用快速康复外科学护理,观察组在对照组基础上采用延续性护理模式。观察2组患者一般资料(包括年龄、性别、体重、手术时间、术中出血等),手术前后SF-36生存质量评分,2组患者术后并发症发生情况,手术前后血清CA125、miR-196a水平,患者满意度等情况。结果2组患者术前生存质量评分差异无统计学意义(P>0.05),术后2组患者生存质量评分较术前显著改善(P<0.05),观察组术后1个月、术后2个月、术后3个月患者生存质量评分明显高于对照组(P<0.05);观察组术后并发症发生率显著高于对照组(P<0.05);术前2组患者CA125水平差异无统计学意义(P>0.05),术后2组患者CA125水平较术前均显著降低,术后1 m、3 m后观察组患者CA125水平显著低于对照组(P<0.05);治疗后2组患者miR-196a水平逐渐降低,且观察组患者术后1 m、3 m血清miR-196a水平显著低于对照组(P<0.05);2组患者健康教育及工作态度满意度差异无统计学意义(P>0.05),观察组患者关爱、心理支持、主动服务以及总体服务满意度明显高于对照组(P<0.05)。结论快速康复外科学护理联合延续性护理干预能有效降低胆囊癌患者术后并发症的发生率及肿瘤标志物水平,提高其生存质量及护理满意度,值得推广。Objective To investigate the effects of rapid rehabilitation surgical nursing on carbohydrate antigen 125(CA125),microrna-196(miR-196a)and the prognosis of patients with gallbladder cancer.Methods A total of 62 patients with gallbladder cancer were enrolled in the study,who were randomly divided into observation group(n=31)and control group(n=31).The patients in control group were treated by rapid rehabilitation surgical nursing,however,the patients in observation group,on the basis of control group,were treated by continuous nursing mode.The general data including age,gender,body weight,operation time,intraoperative bleeding,and SF-36 life quality score before and after operation,the incidence of postoperative complications,the serum levels of CA125 and miR-196a,as well as the satisfaction degree of patients were observed and compared between the two grousp.Results There were no significant differences in the survival quality scores before operation between the two groups(P>0.05).The life quality scores in both groups were significantly improved after operation(P<0.05),moreover,which at 1m,2m and 3m after operation in observation group were significantly higher than those in control group(P<0.05).And the incidence rate of postoperative complications in observation group was significantly higher than that in control group(P<0.05).Before operation there were no significant differences in CA125 levels between the two groups(P>0.05),however,which in both groups after operation were significantly decreased,moreover,which at 1m,3m after operation in observation group were significantly lower than those in control group(P<0.05).In addition there were significant differences in serum levels of miR-196a before and after operation between the two groups(P<0.05),which in both groups after operation were gradually decreased,moreover,which at 1m,3m after operation in observation group were significantly lower than those in control group(P<0.05).The total satisfaction degree of patients in observation group was significantly

关 键 词：胆囊癌 快速康复外科护理 延续性护理 满意度 生存质量 

分 类 号：R473.6[医药卫生—护理学]