CBX家族成员作为独立指标对肺癌患者生存预后的评估价值  

The Value of CBX Family Members as Independent Indicators in Evaluating the Survival of Lung Cancer Patients

作　　者：白玉洁 喻晶[2] 陈海丹[3] 李冬青 Bai Yujie;Yu Jing;Chen Haidan;Li Dongqing(Department of Microbiology,Department of Pathogenic Biology,School of Basic Medical Science,Wuhan University,Wuhan 430071,China;Department of Clinical Laboratory,Hubei Cancer Hospital,Wuhan 430065,China;Department of Spinal Surgery,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]武汉大学基础医学院病原生物学系微生物教研室,湖北武汉430071 [2]湖北省肿瘤医院检验科,湖北武汉430065 [3]三峡大学第一临床医学院[宜昌市中心人民医院]脊柱外科,湖北宜昌443003

出　　处：《巴楚医学》2021年第1期31-37,共7页Bachu Medical Journal

基　　金：国家自然科学基金项目(No:81772839)。

摘　　要：目的:探讨chromobox家族蛋白(CBX)在评估肺癌预后中的作用。方法:在ONCOMINE、UALCAN、Human Protein Atlas、Kaplan-Meier Plotter等数据库中对CBX mRNA和蛋白表达水平以及肺癌患者的生存期等数据进行生物信息学分析和整理。结果:8个CBX成员的表达均与肺癌患者的临床分期(AJCC-TNM分期)显著相关,其中CBX2、CBX4、CBX7和CBX8表达水平增高与肺癌患者总生存率(OS)显著相关,CBX2、CBX4和CBX8表达增高预示肺癌患者预后差,而CBX7表达水平升高预示肺癌患者预后良好。结论:CBX2、CBX4、CBX7和CBX8可以作为检测标志物,用于预测肺癌患者的生存期。Objective:To assess the role of the chromobox family(CBX)in evaluation of the prognosis of lung cancer.Methods:The data including mRNA and protein expression of CBX,as well as survival time of patients with lung cancer sourced from ONCOMINE,UALCAN,Human Protein Atlas,Kaplan-Meier Plotter and other databases were performed with bioinformatics analysis.Results:The results suggested that there were 8 CBX members significantly related to the clinical stage(AJCC-TNM stage)of lung cancer.Among them,the increased CBX2,CBX4,CBX7 and CBX8 were related to the total survival rate(OS)of lung cancer.Elevation of CBX2,CBX4 and CBX8 predicted poor prognosis in patients with lung cancer.While the higher CBX7 level indicated much better prognosis in patients with lung cancer.Conclusion:CBX2,CBX4,CBX7,and CBX8 could be served as the markers for predicting the survival of lung cancer.

关 键 词：肺癌预后 CBX家族蛋白 生物信息学分析 

分 类 号：R319[医药卫生—基础医学]