3D-pCASL与DSC-MRI在急性轻度创伤性脑损伤中的应用价值  

Comparative study on application value of 3D-pCASL and DSC-MRI in acute mild traumatic brain injury

作　　者：喻黎 欧阳林[1] YU Li;OUYANG Lin(Department of Imaging,The Affiliated Dongnan Hospital of Xianen Univversity(909th Hospital of the Joint Logistics Support Force of PLA)Institute of Medical Imaging of Medical College,Xiamen University,Zhangzhou 363000,P.R.China)

机构地区：[1]厦门大学附属东南医院(中国人解放军联勤保障部队第九〇九医院)医学影像科厦门大学医学院医学影像研究所,福建漳州363000

出　　处：《医学影像学杂志》2021年第3期366-370,共5页Journal of Medical Imaging

基　　金：军队后勤科研项目(编号:CLB18J060);福建省自然科学基金面上项目(编号:2015J01365)。

摘　　要：目的探讨三维伪连续式动脉自旋标记(3D-pCASL)技术和动态磁敏感对比磁共振成像(DSC-MRI)技术在急性轻度创伤性脑损伤(mTBI)中的临床应用价值。方法选取25例急性轻度创伤性脑损伤患者的常规MRI、磁敏感加权成像(SWI)、DWI、3D-pCASL和DSC-MRI图像。比较3D-pCASL与DSC-MRI两种灌注成像技术所测得的脑血流量(CBF)与相对脑血流量(rCBF)的差异。结果3D-pCASL与DSC-MRI可发现常规MRI无法显示的mTBI患者脑内血流灌注减低区域。两种技术测量局部脑内低灌注区和对侧镜面区配对t检验结果,CBF(P<0.01)和rCBF(P<0.01)差异有统计学意义。3D-pCASL和DSC-MRI两种方法所测得的CBF与rCBF有显著相关性(r=0.622,P=0.001)。结论3D-pCASL和DSC-MRI技术对显示脑内低灌注病灶具有较好的一致性。这两种方法在评估mTBI患者的局部血流灌注情况方面有很好的应用价值,对临床早期诊断与改善预后具有重要意义。Objective To investigate the clinical application value of three dimensional pulsed continuous arterial spin labeling(3D-pCASL)and dynamic susceptibility contrast-enhanced magnetic resonance imaging(DSC-MRI)in acute mild traumatic brain injury.Methods Routine MRI scan,SWI,DWI,3D-pCASL and DSC-MRI images of 25 patients with acute mild traumatic brain injury were retrospectively analyzed.The differences of 3D-pCASL and DSC-PWI in measurement of cerebral blood flow(CBF)and relative cerebral blood flow(rCBF)were compared.Results 3D-pCASL and DSC-MRI can find areas of hypoperfusion in the brain of patients with mTBI that cannot be shown by conventional MRI.The T-paired test with the two methods was used to measure the low hypoperfusion area and the contralateral mirror area,and CBF(P<0.01)and rCBF(P<0.01)were statistically significant,then there was a signification correlation between(r=0.622,P=0.001).Conclusion The 3D-pCASL technology and DSC-MRI technology have good consistency in displaying cerebral hypoperfusion lesions.The two methods have good application value in the evaluation of local blood perfusion in patients with mTBI,which are of great significance for early clinical diagnosis and improvement of prognosis.

关 键 词：创伤性脑损伤 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]