依托咪酯联合丙泊酚应用于无痛胃肠镜麻醉中的临床效果  

Effect Analysis of Etomidate Combined with Propofol in Painless Gastroscopy Anesthesia

作　　者：孙雪梅[1] 罗莉[1] 康欧 文丰[1] 罗亮[1] SUN Xue-Mei;LUO Li;KANG Ou;WEN Feng;LUO Liang(Department of Anesthesiology,Chengdu Second People's Hospital,Chengdu 610015,China)

机构地区：[1]成都市第二人民医院麻醉科,成都610015

出　　处：《中国药物经济学》2021年第2期53-55,共3页China Journal of Pharmaceutical Economics

摘　　要：目的探讨依托咪酯联合丙泊酚应用于无痛胃肠镜麻醉中的临床效果。方法选取2018年3月至2019年12月成都市第二人民医院收治的78例行无痛胃肠镜麻醉患者作为研究对象,按随机数字表法法分为对照组和观察组,每组39例。对照组采用丙泊酚麻醉,观察组采用依托咪酯联合丙泊酚麻醉,比较两组收缩压(SBP)、舒张压(DBP)、血氧饱和度(SpO_(2))、离室时间、苏醒时间及不良反应发生率。结果麻醉前两组患者SBP、DBP及SpO_(2)比较差异无统计学意义(P>0.05);麻醉后观察组患者SBP、DBP及SpO_(2)高于对照组,差异有统计学意义(P<0.05);观察组患者离室时间和苏醒时间短于对照组,差异有统计学意义(P<0.05);观察组患者恶心呕吐、肌颤和呼吸抑制发生率低于对照组,差异有统计学意义(P<0.05)。结论无痛胃肠镜检查时采用依托咪酯联合丙泊酚麻醉可有效提升麻醉苏醒时间,优化生命体征指标,减少不良反应的发生。Objective To analyze the effect of etomidate combined with propofol in painless gastroscopy anesthesia.Methods A total of 78 patients with painless gastroenteroscopy anesthesia admitted to Chengdu Second People’s Hospital from March 2018 to December 2019 were selected as the research objects and were randomly divided into a control group and an observation group,with 39 cases in each group.Propofol anesthesia was used in the control group,and etomidate combined with propofol anesthesia was used in the observation group.The systolic blood pressure(SBP),diastolic blood pressure(DBP),blood oxygen saturation(SpO_(2)),out-of-room time,recovery time,and incidence of adverse reactions were compared between the 2 groups.Results Before anesthesia,there was no significant difference in SBP,DBP and SpO_(2) between the 2 groups of patients(P>0.05);SBP,DBP,and SpO_(2) in the observation group after anesthesia were higher than those in the control group,and the difference was statistically significant(P<0.05);the room leaving time and wake-up time were shorter than those of the control group,and the difference was statistically significant(P<0.05);the incidence of nausea,vomiting,muscle fibrillation and respiratory depression in the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Etomidate combined with propofol anesthesia in painless gastroenteroscopy can effectively improve the recovery time of anesthesia,optimize life indicators and reduce the occurrence of adverse reactions.

关 键 词：无痛胃肠镜 麻醉 依托咪酯 丙泊酚 呼吸抑制 恶心呕吐 

分 类 号：R971[医药卫生—药品]