Aconapelsulfonines A and B,seco C_(20)-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii  

作　　者：Hui Liu Yuzhuo Wu Qinglan Guo Shuai Shao Chengbo Xu Tiantai Zhang Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2021年第1期33-36,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Sciences Foundation of China(Nos.81630094 and 81573445);CAMS Innovation Fund for Medical Science(Nos.2017-I2M-3-010,2017-I2M-3-011,and 2016-I2M-1-010);The Drug Innovation Major Project(2018ZX09711001-003-001)is acknowledged。

摘　　要：Two sulfo nated seco C_(20)-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the structures were elucidated by various spectroscopic data,combined with X-ray crystallogra phic analysis.The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture.The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test.

关 键 词：RANUNCULACEAE Aconitum carmichaelii C_(20)-Diterpenoid alkaloid Aconapelsulfonine Analgesic activity 

分 类 号：TQ461[化学工程—制药化工]