Multisubstituted pyrazole synthesis via[3+2]cycloaddition/rearrangement/N-H insertion cascade reaction of α-diazoesters and ynones  

作　　者：Peng Zhao Zi Zeng Xiaoming Feng Xiaohua Liu 

机构地区：[1]Key Laboratory of Green Chemistry&Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Chinese Chemical Letters》2021年第1期132-135,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21625205 and U19A2014)。

摘　　要：The cascade reactions of alkyl α-diazoesters and ynones using Al(OTf)_(3) as the catalyst are described.A series of 4-substituted pyrazoles were obtained via [3+2] cycloaddition,1,5-ester shift,1,3-H shift,and N-H insertion process.Deuterium labelling experiments,kinetic studies and control experiments were carried out for the rationalization of the mechanism.

关 键 词：PYRAZOLE Cascade reaction α-Diazoester Ynone Al(OTf)_(3) 

分 类 号：O626.21[理学—有机化学]