Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization  

作　　者：Lu Wang Huaiyu Wang Weidong Meng Xiu-Hua Xu Yangen Huang 

机构地区：[1]Key Laboratory of Science and Technology of Eco-Textiles,Ministry of Education,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China [2]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2021年第1期389-392,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21991123,21677094)for financial support。

摘　　要：3-CF3 S substituted thioflavones and benzothiophenes were achieved via the reactions of AgSCF3 with methylthiolated alkynones and alkynylthioanisoles,respectively,promoted by persulfate.This protocol possesses good functional group tolerance and high yields.Mechanistic studies suggested that a classic two-step radical process was involved,which includes addition of CF3 S radical to triple bond and cyclization with SMe moiety.

关 键 词：Trifluoromethylthiolation Radical cyclization Thioflavone BENZOTHIOPHENE Methylthiolated alkynone Alkynylthioanisole 

分 类 号：O626[理学—有机化学]