Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles  

作　　者：Yuan Zhang Han Luo Qixing Lu Qiaoyu An You Li Shanshan Li Zongyuan Tang Baosheng Li 

机构地区：[1]School of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400030,China

出　　处：《Chinese Chemical Letters》2021年第1期393-396,共4页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(No.21772019);Young Elite Scientist Sponsorship Program by CAST(No.2016QNRC001);The Fundamental Research Funds for the Central Universities(No.2019CDQYHG015);The Basic and Frontier Research Project of Chongqing(No.cstc2018jcyj AX0716);The Venture&Innovation Support Program for Chongqing Overseas Returnees(No.cx2019007)。

摘　　要：We studied the cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones,which were used to construct highly substituted pyridines that are not easily accessed by conventional methods.The strategy addressed some structural diversity issues currently facing medicinal chemistry,and the resulting pyridines could be used as convenient precursors for the synthesis of related pharmaceuticals.In particular,our method was applied to the syntheses of the marketed drug etoricoxib and several biologically important molecules in a few steps.

关 键 词：1 2 3-Triazines PYRIDINES Nucleophilic addition Divergent synthesis Pharmaceuticals synthesis 

分 类 号：O626.32[理学—有机化学] TQ460.1[理学—化学]