Synthetic studies towards(-)-deserpidine:Total synthesis of the stereoisomer and derivative of (-)-deserpidine  

作　　者：Pingzhou Wu Qilong Zhou Xiao-Yu Liu Fei Xue Yong Qin 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]School of Pharmaceutical Sciences and the Innovative Drug Research Centre,Chongqing University,Chongqing 401331,China

出　　处：《Chinese Chemical Letters》2021年第1期401-404,共4页中国化学快报（英文版）

基　　金：the financial surpport from the National Natural Science Foundation of China(Nos.21702140 and21732005);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2018ZX09101003-005-004)。

摘　　要：The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of(-)-deserpidine has been achieved.Key feature s in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring.

关 键 词：Yohimbine alkaloids Deserpidine Photoredox catalytic radical cascade reaction Total synthesis 

分 类 号：TQ283[化学工程—有机化工]