Sulfonylation from sodium dithionite or thiourea dioxide  

作　　者：Fu-Sheng He Min Yang Shengqing Ye Jie Wu 

机构地区：[1]School of Pharmaceutical and Materials Engineering E/Institute for Advanced Studies,Taizhou University,Taizhou 318000,China [2]School of Basic Medicine,Gannan Medical University,Ganzhou 341000,China [3]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2021年第1期461-464,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(Nos.21871053 and 21532001);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005)is gratefully acknowledged。

摘　　要：The cheap and easily available sodium dithionite and thiourea dioxide have been used as the source of sulfonyl group in the synthesis of sulfones and sulfonamides recently.Compared with other methods for the sulfonylation reactions,the strategies using sodium dithionite or thiourea dioxide provide an alternative and complementary route to diverse sulfonyl compounds.During the reaction process,sulfur dioxide anion radical is the key intermediate,which is usually generated from a single electron transfer under suitable conditions.The advantages using sodium dithionite or thiourea dioxide in the sulfonylation reactions include mild conditions and broad substrate scope with excellent functional group compatibility.Further applications by using sodium dithionite and thiourea dioxide in organic transformations will be anticipated.

关 键 词：Sodium dithionite Thioureadioxide SULFONES SULFONAMIDES Sulfur dioxide anion radical 

分 类 号：O621.25[理学—有机化学]