安宫牛黄丸联合丁苯酞治疗缺血性中风  

Clinical efficacy of Angong Niuhuang Pills combined with butylphthalide in treating ischemic stroke

作　　者：崔言坤 付强[2] 高彦宇[2] 李冀[2] CUI Yankun;FU Qiang;GAO Yanyu;LI Ji(Formula-pattern Reasearch Center of Jiangxi University of Traditional Chinese Medicine,Nanchang 330000,China;Heilongjiang University of Chinese Medicine,Harbin 150000,China)

机构地区：[1]江西中医药大学方证研究中心,南昌330000 [2]黑龙江中医药大学,哈尔滨150000

出　　处：《长春中医药大学学报》2021年第2期318-321,共4页Journal of Changchun University of Chinese Medicine

基　　金：国家自然科学基金项目(81874426);黑龙江中医药大学研究生创新基金项目(2018yjscx001)。

摘　　要：目的观察安宫牛黄丸联合丁苯酞对缺血性中风中脏腑闭证患者的临床疗效及血清N端前脑钠肽(NT-pro BNP)、超敏C反应蛋白(hs-CRP)水平的影响。方法将113例急性缺血性中风患者按随机数字表法分为治疗组(57例)与对照组(56例)。在2组均予常规治疗方案的基础上,对照组单一使用丁苯酞注射液(100 mL,每日1次),连续7 d;治疗组在对照组基础上加用安宫牛黄丸(每日1丸,口服或鼻饲),连续7 d。治疗前后分别观察并记录2组临床疗效、神经功能缺损评分(NIHSS),格拉斯哥昏迷指数(GCS)评分和不良反应发生率,并检测2组治疗前后血清NT-pro BNP和hs-CRP水平。结果治疗后,2组NIHSS和GCS评分均显著改善(P<0.05),治疗组NIHSS和GCS评分显著优于对照组(P<0.05);治疗后,2组NT-pro BNP与hs-CRP水平均显著下降(P<0.05),且治疗组下降明显;治疗组不良反应发生率低于对照组(P<0.05)。结论安宫牛黄丸联合丁苯酞能有效改善缺血性中风患者神经功能缺损,降低不良反应发生率。Objective To observe the clinical effect of Angong Niuhuang Pills combined with butylphthalide on ischemic stroke patients with viscera blocking syndrome and its influence on serum N-terminal pro-brain natriuretic peptide(NT-pro BNP)and high-sensitivity C-reactive protein(hs-CRP)levels.Methods 113 patients with acute ischemic stroke were divided into treatment group(57 cases)and control group(56 cases)according to a random number table method.On the basis of the conventional treatment plan in both groups,the control group was only treated with butylphthalide injection(100 mL,1 per day)for 7 consecutive days,while the treatment group was additionally given Angong Niuhuang Pills(1 pill a day,oral or nasal feeding)on the basis of the control group for 7 consecutive days.The clinical efficacy,neurological deficit score(NIHSS),Glasgow coma index(GCS)score and the incidence of adverse reactions were observed and recorded in the two groups before and after treatment.Serum NT-pro BNP and hs-CRP levels in the two groups were also detected before and after treatment.Results After treatment,the NIHSS and GCS scores of the two groups were significantly improved(P<0.05),and the NIHSS and GCS scores of the treatment group were significantly better than those of the control group(P<0.05).After treatment,the levels of NT-pro BNP and hs-CRP in the two groups were both significantly decreased(P<0.05),and the treatment group decreased much more significantly.The incidence of adverse reactions in the treatment group was significantly lower than that of the control group(P<0.05).Conclusion Angong Niuhuang Pills combined with butylphthalide can effectively improve the neurological deficit of patients with ischemic stroke,reduce the incidence of adverse reactions,and is conductive to the prognosis.

关 键 词：安宫牛黄丸 中风中脏腑 丁苯酞 超敏C反应蛋白 N端前脑钠肽 

分 类 号：R255.2[医药卫生—中医内科学]