基于肠-肝-肾轴的肝纤维化与肾纤维化研究进展  

Progress in understanding hepatic fibrosis and renal fibrosis based on the gut-liver-kidney axis

作　　者：王明亮 丁永芳[1,2] 印鑫 邵久针 庄子锐 张婷[1,2] 苏鹏亮 彭蕴茹 WANG Ming-liang;DING Yong-fang;YIN Xin;SHAO Jiu-zhen;ZHUANG Zi-rui;ZHANG Ting;SU Peng-liang;PENG Yun-ru(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210028 [2]江苏省中医药研究院,江苏南京210028

出　　处：《药学学报》2021年第1期9-20,共12页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81774178,81373888)。

摘　　要：纤维化是组织受到损伤后,组织内细胞外基质异常增生和过度沉积的病理过程。各类慢性疾病导致的损伤/炎症是纤维化发生的主要诱因。肝和肾的纤维化是较常见的脏器纤维化。近年来,肠道微生物群被证明与肝肾相关疾病的发展进程有密切关联,其内在机制可能与肠道微生物的组成变化以及肠道完整性等相关。肠-肝-肾三者之间通过内分泌和细胞信号通路等各种途径进行相互影响并促进肝和(或)肾纤维化的发展。本文基于肠-肝肾轴对肝纤维化与肾纤维化的相关研究进展进行综述,以期为诊疗肝肾纤维化提供新的策略和理论依据。Fibrosis is a pathological process of abnormal hyperplasia and excessive deposition of extracellular matrix during the process of repair after tissue and organ damage.Injury/inflammation caused by variously chronic diseases is a major trigger for fibrogenesis.Fibrosis of the liver and kidney is a common organ fibrosis.Recently,the intestinal microbiota has been shown to be extensively involved in the development of liver and kidney diseases,which may follow from changes in the intestinal microbial composition and intestinal integrity.This promotes the development of liver and/or kidney fibrosis through endocrine,cell signaling and other pathways.This paper reviews the research progress in understanding liver fibrosis and kidney fibrosis based on the gut-liver-kidney axis,which may be helpful for providing new strategies and theoretical basis for the diagnosis and treatment of hepatic and renal fibrosis.

关 键 词：纤维化 肝-肾轴 肠-肝轴 肠-肾轴 肠-肝-肾轴 

分 类 号：R373.1[医药卫生—病原生物学]