microRNA介导低氧对药物代谢酶和转运体的调控  

Effect of hypoxia on drug metabolizing enzymes and transporters and the role of microRNA

作　　者：段雅彬 朱俊博 杨建鑫 李向阳[1,2] DUAN Ya-bin;ZHU Jun-bo;YANG Jian-xin;LI Xiang-yang(Research Center for High Altitude Medicine,Qinghai University,Xining 810001,China;State Key Laboratory of Plateau Ecology and Agriculture,Qinghai University,Xining 810016,China)

机构地区：[1]青海大学高原医学研究中心,青海西宁810001 [2]青海大学三江源生态与高原农牧业国家重点实验室,青海西宁810016

出　　处：《药学学报》2021年第1期50-60,共11页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81760673,81460568);青海省基础研究计划项目(2019-ZJ-918).

摘　　要：低氧条件下机体的循环系统、神经系统、内分泌系统等的功能发生显著改变,这些变化影响药物在体内的吸收、分布、代谢和排泄。药物代谢酶和转运体是影响药物代谢的主要因素,微小RNA(microRNA,miRNA)除调控与药物代谢相关的基因如缺氧诱导因子、炎症因子、核受体等,还可直接作用于药物代谢酶和转运体,影响药物的体内代谢。本文通过综述低氧对miRNA及药物代谢酶和转运体的调节,miRNA调控药物代谢酶和转运体及药物代谢相关基因,低氧调节药物代谢酶和转运体的相关机制等,探讨miRNA在低氧调节药物代谢酶和转运体中的作用,提出以miRNA为核心的低氧影响药物代谢的分子机制。The function of circulatory system,nervous system and endocrine system is significantly changed in hypoxic environments.These changes affect the absorption,distribution,metabolism,and excretion of drugs in the body.Drug metabolizing enzymes and transporters are the main factors affecting drug metabolism;microRNA(miRNA)can act directly on drug metabolizing enzymes and transporters and can regulate their genes through hypoxia-inducible factor,inflammatory cytokines,and nuclear receptors.This article reviews the effect of hypoxia on drug metabolizing enzymes and transporters and the mechanisms by which miRNA modulates these proteins and their expression during hypoxia.

关 键 词：MIRNA 低氧 药物代谢酶 药物转运体 

分 类 号：R917[医药卫生—药物分析学]