天然低共熔溶剂在药剂学中的应用  

Application of natural deep eutectic solvents in pharmaceutics

作　　者：宣婧婧 武喜营 戚建平[4] 庄婕 XUAN Jing-jing;WU Xi-ying;Qi Jian-ping;ZHUANG Jie(Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;Shanghai Dermatology Hospital,Shanghai 200443,China;School of Pharmacy,Fudan University,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学研究生院,上海201203 [2]上海健康医学院药学院,上海201318 [3]上海皮肤病医院,上海200443 [4]复旦大学药学院,上海201203 [5]上海中医药大学,上海201203

出　　处：《药学学报》2021年第1期146-157,共12页Acta Pharmaceutica Sinica

摘　　要：天然低共熔溶剂是一种由生物相容性好的天然物质作为氢键供体和受体所构成的低共熔溶剂,如胆碱、氨基酸和糖等,具有低成本、易制备及环境友好等优点,已在许多领域中有着广泛的应用。由于其生物相容性好,使用较为安全,特别适用于医药领域。本文首先从天然低共熔溶剂的形成原理出发,对目前所采用的分子模拟设计方法进行了综述;然后对目前天然低共熔溶剂所使用材料和制备方法进行了总结,并阐述了其理化性质;最后对其目前在药剂学中的应用进行了总结,包括增加药物溶解度、促进药物渗透性、促进药物口服吸收等,并对其在药剂学中的应用前景进行展望。Natural deep eutectic solvent(NDES)is a kind of deep eutectic solvents(DESs)which is composed of natural substances with good biocompatibility.Those substances can function as hydrogen bond donor and acceptor,such as choline,amino acids,sugars,etc.NDES have been widely used in many fields due to their advantages of low cost,easy preparation and environmental friendliness.It is especially suitable for the pharmaceutical industry because of its good biocompatibility and safety for use.In this paper,we firstly review the molecular simulation methods for current design of DESs from the formation principle.And then,the materials and preparation of NDES are reviewed and the physicochemical properties are further described.Finally,we review the current application of NDES in pharmaceutics including increasing drug solubility,promoting drug permeability and enhancing oral drug absorption,and meanwhile their future applications in pharmaceutics were also prospected.

关 键 词：天然低共熔溶剂 离子液体 增溶 促渗 药物低共熔物 

分 类 号：R943[医药卫生—药剂学]