膜联蛋白B1在猪囊尾蚴免疫逃避作用的研究进展  

Research Progress of Annexin B1 in Immune Evasion of Cysticercus Cellulosae

作　　者：于铭川 王昕蕊 宋伟宜 宋伊宁 杨景芳[2] 孙树民[1] Yu Mingchuan;Wang Xinrui;Song Weiyi;Song Yining;Yang Jingfang;Sun Shumin(College of Animal Science and Technology,Inner Mongolia University for Nationalities,Tongliao Inner Mongolia 028000;Livestock Breeding Guidance Station in Tongliao Inner Mongolia,Tongliao Inner Mongolia 028000)

机构地区：[1]内蒙古民族大学动物科技学院,内蒙古通辽028000 [2]内蒙古通辽市家畜繁育指导站,内蒙古通辽028000

出　　处：《中国农学通报》2021年第8期110-115,共6页Chinese Agricultural Science Bulletin

基　　金：国家重点研发计划课题“猪囊虫病早期诊断与阻断及免疫预防制剂开发”(2017YFD0501303);国家自然科学基金项目“猪囊尾蚴丝氨酸蛋白酶抑制剂介导免疫逃避的分子机制研究”(31960707);国家自然科学基金项目“猪带绦虫/囊尾蚴不同发育时期标识性抗原基因的筛选”(31460658);国家自然科学基金项目“我国旋毛虫属分类鉴定和分子进化研究”(31160504);内蒙古自治区自然科学基金“旋毛虫感染引发宿主高度免疫抑制的分子机制研究”(2017MS0321)。

摘　　要：膜联蛋白是一类有效的内源性调节蛋白,在Ca2+存在的条件下与膜磷脂结合,参与细胞活动的多种功能,其与肿瘤发生、自身免疫性疾病、病毒和寄生虫感染等密切相关。作为膜联蛋白家族成员Annexin B1具有独特的氨基酸残基结构,与不同种属的寄生虫入侵特异性宿主密切相关。本文主要阐述了膜联蛋白的种类及膜联蛋白B1在猪囊尾蚴感染宿主机体过程中免疫逃避的作用,旨在探索其猪囊尾蚴感染的免疫逃避机制。深入对膜联蛋白B1和囊尾蚴之间相互关系的进一步了解,以及膜联蛋白B1在寄生虫免疫中更深入的研究,对寄生虫免疫逃避的生物学意义和寄生虫病诊断治疗提供了相关的策略。Annexin is a type of effective endogenous regulatory protein, which binds to membrane phospholipids in the presence of Ca2 +and participates in various functions of cell activities. It is closely related to tumorigenesis, autoimmune diseases, viral and parasitic infections, etc. As a member of the annexin family, annexin B1 has a unique structure of amino acid residues and is closely related to the invasion of specific hosts by different species of parasites. This article mainly describes the types of annexin and the role of annexin B1 in the immune evasion process of Cysticercus cellulosae infecting the host, aiming to explore the immune evasion mechanism of Cysticercus cellulosae infection. A further understanding of the relationship between annexin B1 and cysticercus, as well as a more in-depth study of annexin B1 in parasite immunity could provide relevant information on the biological significance of parasite immune evasion and the diagnoses and treatment of parasitic diseases.

关 键 词：膜联蛋白B1 调节蛋白 囊尾蚴 凋亡 免疫逃避机制 

分 类 号：S855.9[农业科学—临床兽医学]