三维打印光热功能骨支架在颌面部肿瘤骨缺损修复应用中的研究进展  

Advances in the application of three-dimensional photothermal functionalized scaffold for bone repairation after maxillofacial tumor surgery

作　　者：李凤集 李瑞欣 邹慧儒[3] 王爽 刘浩[1] Li Fengji;Li Ruixin;Zou Huiru;Wang Shuang;Liu Hao(Department of Oral Maxillofacial Surgery,Tianjin Stomatological Hospital&Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin 300041,China;Tianjin Stomatological Hospital&Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin 300041,China;Department of Endodontics,Tianjin Stomatological Hospital&Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin 300041,China;Graduate School of Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津市口腔医院口腔颌面外科,天津市口腔功能重建重点实验室,300041 [2]天津市口腔医院,天津市口腔功能重建重点实验室,300041 [3]天津市口腔医院牙体牙髓科,天津市口腔功能重建重点实验室,300041 [4]天津医科大学研究生院,300070

出　　处：《中华口腔医学杂志》2021年第3期283-287,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(11972198);天津市临床医学重点学科专项(HWZX001);天津市科技计划项目(19ZXDBSY00070)。

摘　　要：颌面部肿瘤的传统治疗方法包括手术和放化疗。手术风险较高,术后形成大块骨缺损,较难自行修复;而放化疗的不良反应较严重。因此,如何修复颌面部肿瘤术后的骨缺损,同时预防肿瘤复发成为临床上的重大挑战。近年来,光热疗法因侵入性小、高效且无不良反应备受关注,越来越多的光热材料也应运而生,并应用于光热治疗。为治疗肿瘤相关的骨缺损,很多研究利用三维打印技术制备光热功能骨支架,在修复手术后骨缺损的同时预防肿瘤复发。本文归纳和总结了光热材料、骨修复材料和光热功能骨支架在颌面部肿瘤治疗中的国内外研究进展,为解决颌面部肿瘤术后骨缺损及肿瘤复发这一临床挑战提供新思路。The traditional treatment of maxillofacial tumors includes surgery and chemoradiotherapy.Surgery carries a high risk,and large bone defects are difficult to repair themselves.Besides,chemoradiotherapy can bring serious side effects.Therefore,how to repair the bone defects after maxillofacial tumor surgery and prevent tumor recurrence has become a major clinical challenge.In recent years,photothermal therapy has attracted much attention because of its low invasion,high efficiency,and no side effects.More and more photothermal materials have emerged and been applied in photothermal therapy.In order to treat tumor-related bone defects,many studies use three-dimensional printing technology to prepare photothermal functionalized scaffold to repair bone defects and prevent the recurrence of tumors.Based on photothermal therapy,the review states the photothermal materials,bone repair materials and photothermal functionalized scaffolds in the treatment of maxillofacial tumors at home and abroad,and provides a new way to solve the clinical challenge of bone defect and tumor recurrence after maxillofacial tumor surgery.

关 键 词：面部肿瘤 光热治疗 三维打印 光热功能骨支架 

分 类 号：R318.08[医药卫生—生物医学工程] R739.8[医药卫生—基础医学]