脂质体药物递送系统在口腔医学中的研究进展  

Research progress of liposome drug delivery system in stomatology

作　　者：胡志民 刘思颖[1] 杨宏业[1] 黄翠[1] Hu Zhimin;Liu Siying;Yang Hongye;Huang Cui(The State Key Laboratory Breeding Base of Basic Science of Stomatology&Key Laboratory of Oral Biomedicine Ministry of Education,School of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医学院口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室,430079

出　　处：《中华口腔医学杂志》2021年第3期294-300,共7页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81600894,81771112)。

摘　　要：脂质体是磷脂分散在水性介质中自发形成的具有双层膜结构的球形囊泡,具有两亲性质,是一种优良的药物载体。脂质体具有良好的生物相容性、可生物降解以及无免疫原性等特点,可靶向递送并持续释放负载药物,增强药物的溶解性,提升药物的稳定性,降低药物的毒性,提高负载药物的治疗效果。近年,脂质体药物递送系统在口腔医学中的研究和应用已十分广泛,本文从脂质体药物递送系统在龋病、牙髓疾病、牙周炎、口腔种植、口腔麻醉和口腔念珠菌病等领域的研究和应用作一综述。Liposomes are spherical vesicles with bilayer membrane structure spontaneously formed by phospholipids dispersed in an aqueous medium.Liposomes are excellent drug carrier with amphiphilic properties.Liposomes have good biocompatibility,biodegradability and no immunogenicity.Liposomes can achieve the delivery of the drug,enhance the solubility,improve the stability,reduce the toxic effect of the drug,and improve the therapeutic effect of the loaded drug.In recent years,liposome drug delivery systems have been widely used in dentistry.This article reviews the application of liposome drug delivery systems in caries,dental pulp diseases,periodontitis,implantation,oral anesthesia and oral candidiasis.

关 键 词：脂质体 口腔医学 药物递送系统 

分 类 号：R943[医药卫生—药剂学] R78[医药卫生—药学]