喜炎平注射液辅助治疗儿童毛细支气管炎的临床疗效及安全性  

Clinical efficacy and safety of Xiyanping injection in the adjuvant treatment of bronchiolitis in children

作　　者：赵秀侠 马香[1] 韩玉玲[1] ZHAO Xiuxia;MA Xiang;HAN Yuling(Jinan Children’s Hospital,Shandong Province,Jinan 250022,China)

机构地区：[1]济南市儿童医院,250022

出　　处：《临床合理用药杂志》2021年第4期44-46,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察喜炎平注射液辅助治疗儿童毛细支气管炎的临床疗效及安全性。方法选取2016年10月-2017年3月在济南市儿童医院呼吸科住院的毛细支气管炎患儿126例,根据治疗方法不同分为试验组96例及对照组30例。对照组患儿给予吸氧、雾化及止咳祛痰等常规治疗,试验组在常规治疗的基础上加用喜炎平注射液治疗。比较2组临床疗效、临床症状恢复时间,治疗前、治疗第2、4、6天咳嗽、喘息症状评分,不良反应。结果试验组的总有效率为94.79%,明显高于对照组的63.33%(χ^(2)=20.404,P=0.000)。试验组咳嗽、喘息好转时间、肺啰音消失时间均短于对照组(P <0.01)。2组治疗前、治疗第2天咳嗽及喘息症状评分比较差异均无统计学意义(P>0.05);治疗第4天及第6天,试验组的咳嗽及喘息症状评分均明显低于对照组(P <0.01)。试验组发生皮疹1例(1.04%),腹泻2例(2.08%),不良反应轻微,经对症处理均很快缓解;对照组无不良反应。结论喜炎平注射液辅助治疗儿童毛细支气管炎有较好的临床疗效,可迅速改善患儿的临床症状,且安全性较高。Objective To observe the clinical efficacy and safety of Xiyanping injection in the adjuvant treatment of bronchiolitis in children. Methods 126 children with bronchiolitis hospitalized in the Department of Respiratory,Jinan Children’s Hospital from October 2016 to March 2017 were selected. According to different treatment methods,96 cases were divided into experimental group and 30 cases were divided into control group. The control group was given routine treatment such as oxygen inhalation,atomization,cough and expectoration,while the experimental group was given intravenous drip of Xiyanping injection on the basis of routine treatment. The clinical efficacy,recorvery time of clinical symptoms,scores of cough and wheezing symptoms and adverse reactions before treatment and on day 2,4 and 6 were compared between the two groups.Results The total effective rate of experimental group was 94. 79%,significantly higher than the 63. 33% in the control group( χ^(2)= 20. 404,P = 0. 000). The time to improve cough,wheezing,and the disappearance of pulmonary rales in the experimental group were shorter than those in the control group( P < 0. 01). There were no significant difference in the scores of cough and wheezing between the two groups before treatment and on the second day of treatment( P > 0. 05);On the 4 th and6 th day of treatment,the scores of cough and wheezing in the experimental group were significantly lower control group( P <0. 01). In the test group,1 case( 1. 04%) had skin rash,and 2 cases( 2. 08%) had diarrhea,the adverse reactions were mild and alleviated quickly after symptomatic treatment;the control group had no adverse reactions. Conclusion Xiyanping injection has a good clinical effect in adjuvant treatment of bronchiolitis in children,can quickly improve the clinical symptoms of children,and has high safety.

关 键 词：喜炎平注射液 毛细支气管炎 儿童 临床疗效 安全性 

分 类 号：R725.6[医药卫生—儿科]