Dynamic versus static ultra-widefield fluorescein angiography in eyes with diabetic retinopathy:a pilot prospective cross-sectional study  

作　　者：Hang-Qi Shen Jing Wang Tian Niu Ji-Li Chen Xun Xu 

机构地区：[1]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [2]Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [3]Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Gencral Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [4]Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [5]National Clinical Research Center for Eye Diseases,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [6]Department of Ophthalmology,Shanghai Shibei Hospital of Jing'an District,Shanghai 200435,China

出　　处：《International Journal of Ophthalmology(English edition)》2021年第3期409-415,共7页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.81570851);Project of Shanghai Medical Key Specialty Construction(No.ZK2019B27);National Project of Shanghai Municipal Commission of Health and Family Planning(No.201740001);Project of Shanghai Jingan District Municipal Commission of Health and Family Planning(No.2018MS12);Advanced and Appropriate Technology Promotion Project of Shanghai Health Commission(No.2019SY012);Shanghai Jiao Tong University Translation Medicine Cross Research Fund Project(No.YG2019QNA61)。

摘　　要：AIM:To analyze differences in ultra-widefield fluorescein angiography(UWFA)findings between dynamic and static images of eyes with diabetic retinopathy(DR).METHODS:This cross-sectional study included 28 eyes of 28 patients with DR undergoing UWFA.A series of UWFA images acquired from each patient were converted into a time-lapse video and used as a dynamic image.A single,clear,arteriovenous phase image was chosen as a static image.Non-perfusion index(NPI)and its correlation with vascular abnormalities in different zones were compared between dynamic and static UWFA imaging.RESULTS:NPI appeared to increase from the center to the far-periphery in both groups.Dynamic NPI was lower in the total retinal area(0.26 vs 0.29,P=0.009)and farperiphery(0.33 vs 0.36,adjusted P=0.042),which was contrary to the static NPI.Far-peripheral NPI was associated with intraretinal microvascular abnormality in the posterior area in both groups.CONCLUSION:Time-lapse dynamic UWFA imaging is a useful modality to differentially diagnose hypofluorescence in the most peripheral region.This modality could provide a reliable method for NPI measurement.

关 键 词：diabetic retinopathy ultra-widefield fluorescein angiography non-perfusion index time-lapse photography 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]