HIF-1α在骨组织细胞代谢及骨疾病中的调控作用  

Regulatory Effects of HIF-1αin Bone Cell Metabolism and Bone Diseases

作　　者：刘莉菲 仝晓阳 郭健民[1] 陈熙[3] 杨杰[4] LIU Lifei;TONG Xiaoyang;GUO Jianmin;CHEN Xi;YANG Jie(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;Rehabilitation Department,People’s Hospital of China Medical University,People's Hospital of Liaoning Province,Shenyang 110016,China;School of Sports Science,Wenzhou Medical University,Wenzhou 325035,China;Affiliated School of Elite Sport,Shanghai University of Sport,Shanghai 200438,China)

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]中国医科大学人民医院,辽宁省人民医院康复医学科,沈阳110016 [3]温州医科大学体育科学学院,温州325035 [4]上海体育学院附属竞技体育学校,上海200438

出　　处：《中国细胞生物学学报》2021年第2期469-475,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81702235);温州市应用基础研究项目(批准号:Y20190019);上海市人类运动能力开发与保障重点实验室(上海体育学院)项目(批准号:11DZ2261100)资助的课题。

摘　　要：低氧诱导因子-1α(HIF-1α)是调节细胞对低氧应答的关键因子,可在氧含量降低时被激活,能够调节氧代谢、糖酵解等多种生理活动。骨代谢主要包括骨形成和骨吸收作用,均受到氧浓度等多种因素的调控。HIF-1α在细胞代谢、骨组织生理及病理过程的调控中起着重要的作用,能够增加骨组织的低氧耐受能力,调节骨形成和矿化过程。该文主要综述了HIF-1α对成骨细胞、破骨细胞、骨髓间充质干细胞、软骨细胞等骨组织细胞的调控,对骨血管形成过程的影响,以及对肿瘤骨转移、股骨头坏死、异位骨化等病理过程的调节作用,为探讨HIF-1α对骨代谢的调控和相关疾病的治疗提供参考。HIF-1α(hypoxia-inducible factor-1α)is a key factor that regulates the response of cells to hypoxia.It can be activated when the oxygen content is reduced,and regulates various physiological activities such as oxygen metabolism and glycolysis.Bone metabolism mainly includes bone formation and bone resorption,both of which are regulated by various factors such as oxygen concentration.HIF-1αplays an important role in the regulation of cell metabolism,as well as bone tissue physiology and pathological processes,which can increase the hypoxia tolerance of bone tissue,and regulate bone formation and mineralization.This article mainly reviews the physiological regulation process of HIF-1αon the metabolism and angiogenesis of osteoblasts,osteoclasts,bone marrow mesenchymal stem cells,chondrocytes and other bone cells.The effects of HIF-1αon the formation of bone vessels,bone metastasis,femoral head necrosis and heterotopic ossification are also reviewed.This review provides a theoretical reference for exploring the regulation of HIF-1αon bone metabolism and the treatment of related diseases.

关 键 词：低氧诱导因子-1Α 骨代谢 骨形成 

分 类 号：R68[医药卫生—骨科学]