Body mass index is a promising predictor of response to oral rehydration saline in children with vasovagal syncope  

作　　者：Chun-Yan Tao Selena Chen Xue-Ying Li Chao-Shu Tang Jun-Bao Du Hong-Fang Jin 

机构地区：[1]Department of Pediatrics,Peking University First Hospital,Beijing 100034,China [2]Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases,Chinese Academy of Medical Sciences,Beijing 100730,China [3]Division of Biological Sciences,University of California,San Diego,CA 92093,USA [4]Department of Medical Statistics,Peking University First Hospital,Beijing 100034,China [5]Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100191,China

出　　处：《Chinese Medical Journal》2021年第4期463-468,共6页中华医学杂志（英文版）

基　　金：This work was supported by grants from the Peking University Medicine Fund of Fostering Y oung Scholars'Scientifie&Technological Innovation,Peking University Clinical Medicine Plus X-Young Scholars Project(PKU2019LCXQ011);the Peking University Clinical Scientist Program(No.BMU2019LCKXJ001)and the Fundamental Research Funds for the Central Universities.

摘　　要：Background:Vasovagal syncope(VVS)greatly impairs quality of life.The therapeutic efficacy of oral rehydration saline(ORS)for unselected VVS patients is not satisfactory due to the diverse mechanisms of the disease.Body mass index(BMI)was demonstrated to reflect blood volume to a certain extent.Therefore,the present study explored the capability of BMI to predict the therapeutic response of children with VVS to ORS treatment.Methods:Seventy-four children with VVS who visited the Syncope Unit of Pediatrics at Peking University First Hospital from November 2010 to June 2019 receiving ORS treatment were enrolled for this retrospective case-control study.A comparison of demographic,clinical,and hemodynamic characteristics was performed between responders and non-responders.The correlation between baseline BMI and response time was analyzed.To determine the value of baseline BMI in predicting the therapeutic efficacy of ORS in children with VVS,a receiver operating characteristic curve analysis was performed.Results:Fifty-two children were identified as responders,and the remaining 22 children were identified as non-responders.The baseline BMI of the responders was much lower than that of the non-responders(16.4[15.5,17.8]kg/m2vs.20.7±3.6 kg/m2,P<0.001),and baseline BMI was positively correlated with response time in the head-up tilt test after adjusting for sex(r=0.256,95%confidence interval[CI]:0.067-0.439,P=0.029).The area under the receiver operating characteristic curve of baseline BMI was 0.818(95%CI:0.704-0.932,P<0.001),and an optimal cut-off value of 18.9 kg/m2 yielded a sensitivity of 83%and a specificity of 73%to predict the efficacy of ORS in VVS.Conclusion:Prior to treatment,baseline BMI is a promising predictor of response to ORS in children with VVS.

关 键 词：Vasovagal syncope Oral rehydration saline Body mass index Therapeutic response 

分 类 号：R725[医药卫生—儿科]