Evaluation of toxicity profiles of rare earth elements salts(lanthanides)  

作　　者：M.Rucki K.Kejlov A.Vlkov D.Jirova M.Dvorakova L.Svobodova H.Kandarova S.Letasiova H.Kolarova M.Mannerstrom T.Heinonen 

机构地区：[1]National Institute of Public Health,Srobarova 49/48,10000 Prague.Czech Republic [2]Centre of Experimental Medicine SAS,Slovak Academy of Sciences,Dubravska Cesta 9,84104 Bratislava.Slovakia [3]MatTek In Vitro Life Science Laboratories,Mlynske Nivy 73,82105 Bratislava,Slovakia [4]Department of Medical Biophysics,Faculty of Medicine and Dentistry,Palacky University,Hnevotinska 3,77515 Olomouc,Czech Republic [5]FICAM,Faculty of Medicine and Health Technology,FI-33014 Tampere University,Tampere,Finland

出　　处：《Journal of Rare Earths》2021年第2期225-232,共8页稀土学报（英文版）

基　　金：the ERDF/ESF project“International Competitiveness of NIPH in Research,Development and Education in Alternative Toxicological Methods”(CZ.02.1.01/0.0/0.0/16019/0000860);by Ministry of Health,Czech Republic-Conceptual Development of Research Organization(National Institute of Public Health-NIPH,75010330)。

摘　　要：The presented study aims to extend the knowledge of toxicological profile of rare earth elements salts(REEs).The basal toxicity test performed comprised assessment of cytotoxicity(3 T3 Balb/c Neutral Red Uptake Test)that allows for calculation of LD50(rats)on the basis of the concentration which leads to a50%reduction in cell growth(IC50).Environmental toxicity was addressed by the Tubifex tubifex(T.t.)express test.The in vitro skin irritation(OECD TG 439)and skin corrosion tests(OECD TG 431)utilizing the 3 D in vitro reconstructed human epidermal model EpiDerm(MatTek IVSL,SK)were used for assessment of skin irritation and corrosion potential hazard of REEs.Mutagenic effects were determined using the bacterial reverse mutation assay(Ames Test)on 5 Salmonella typhimurium strains with and without metabolic activation(OECD TG 471).Endocrine disruption was evaluated by means of a yeastbased assay YES/YAS(Xenometrix,CH).Skin sensitization was assessed using the LuSens assay,based on a genetically modified human keratinocyte cell line(OECD TG 442 D).The tested REEs have no potential of mutagenicity or skin sensitization,exhibit very weak endocrine disruption potential and only exceptional local irritation/corrosion effects for thulium(Ⅲ)chloride anhydrous,but have acute and chronic toxic effects on the aquatic environment.

关 键 词：LANTHANIDES Rare earth elements Local toxicity Systemic toxicity ECOTOXICITY 

分 类 号：TQ133.3[化学工程—无机化工]