microRNA调控结核分枝杆菌感染巨噬细胞凋亡的研究进展  

Progress in microRNA regulating apoptosis of Mycobacterium tuberculosis-infected macrophages

作　　者：王方璐 王文涛 伊正君[2] 付玉荣[1] Wang Fanglu;Wang Wentao;Yi Zhengjun;Fu Yurong(Clinical Medical College of Weifang Medical University,Weifang 261053,China;Department of Clinical Laboratory,Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院临床医学院,261053 [2]潍坊医学院医学检验学系,261053

出　　处：《中华微生物学和免疫学杂志》2021年第2期143-148,共6页Chinese Journal of Microbiology and Immunology

基　　金：山东省自然科学基金面上项目和重大基础研究项目(R2018MH001,ZR2018ZC1054)。

摘　　要：细胞凋亡对于机体抑制或清除胞内结核分枝杆菌(Mycobacterium tuberculosis,Mtb)尤为重要,Mtb感染巨噬细胞后,往往会诱导机体启动一系列机制调控巨噬细胞凋亡。在Mtb感染的巨噬细胞内存在差异表达的microRNAs(miRNAs),miRNA可直接结合凋亡基因的3′UTR(3′-untranslated region)非翻译区结合位点,通过调控凋亡基因表达参与线粒体或死亡受体途径调控巨噬细胞凋亡。本文综述了现阶段与Mtb感染巨噬细胞凋亡的相关miRNAs及其调控巨噬细胞凋亡的主要机制。Apoptosis is particularly important for the body to inhibit or eliminate Mycobacterium tuberculosis(Mtb)infection.A series of mechanisms to regulate macrophage apoptosis are triggered after macrophages are infected by Mtb.In Mtb-infected macrophages,there are differentially expressed microRNAs(miRNAs),which can directly bind to the binding sites in the 3′-untranslated region(3′UTR)of apoptotic genes to regulate the expression of apoptotic genes and the apoptosis of macrophages through the mitochondrial or death receptor pathway.This paper reviewed the miRNAs associated with the apoptosis of Mtb-infected macrophages and the major mechanisms.

关 键 词：MICRORNA 结核分枝杆菌 巨噬细胞 细胞凋亡 

分 类 号：R392[医药卫生—免疫学]