HBV疫苗接种后高、低、无应答个体B细胞特征的研究进展  

Research progress in characteristics of B cells in high-,low-and non-responsive individuals after HBV vaccination

作　　者：杨廷雯 孙丽娜 贺晓燕 姚新生 Yang Tingwen;Sun Lina;He Xiaoyan;Yao Xinsheng(Immunology Laboratory,Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]遵义医科大学免疫学教研室,563003

出　　处：《中华微生物学和免疫学杂志》2021年第2期159-164,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81860300,82060307);贵州省百层次人才基金([2018]5637)。

摘　　要：乙型肝炎病毒(hepatitis B virus,HBV)感染一直以来都是世界范围内严重的公共卫生问题,可导致急、慢性肝脏疾病以及多种并发症。接种HBV疫苗诱导机体B细胞分泌保护性的乙型肝炎病毒表面抗体(hepatitis B surface antibody,HBsAb)是预防HBV感染最重要的措施。研究表明不同个体对HBV疫苗应答的效应不一致,可分为超高/高、正常/中等、低/无应答,对其产生机制的研究可为高滴度HBsAb制备、HBV感染防治等提供参考。本文将对HBV疫苗接种后不同应答效应个体B细胞特征和机制的研究概况与进展进行综述。Hepatitis B virus(HBV)infection remains a serious global health problem,which can lead to acute and chronic liver diseases and a variety of complications.HBV vaccination,which induces B cells to secrete protective hepatitis B surface antibody(HBsAb),is an important measure to prevent HBV infection.Some studies have shown that different individuals have different responses to HBV vaccine,which can be divided into ultra-high/high,normal/medium and low/non-response.Research on the potential mechanisms can provide reference for the preparation of high-titer HBsAb and the prevention and treatment of HBV infection.This paper reviewed the research situation and progress in the characteristics and mechanism of B cells in different responders after HBV vaccination.

关 键 词：乙型肝炎病毒疫苗 免疫接种和应答 B细胞 B细胞抗原受体互补决定区3受体库 

分 类 号：R392-3[医药卫生—免疫学]