复方苁蓉益智胶囊治疗帕金森病肝肾亏虚型失眠的疗效观察  

Effect on Compound Congrong Yizhi Capsules in treatment of insomnia of liver and kidney deficiency in Parkinson’s disease

作　　者：李红果 LI Hongguo(Department of TCM,The Fourth Hospital of Changsha,Changsha 410000,China)

机构地区：[1]长沙市第四医院中医科,湖南长沙410000

出　　处：《药物评价研究》2021年第2期390-393,共4页Drug Evaluation Research

摘　　要：目的探讨复方苁蓉益智胶囊治疗帕金森病肝肾亏虚型失眠患者的临床疗效。方法选取2019年1月—2020年6月长沙市第四医院帕金森疾病肝肾亏虚证型失眠患者60例作为研究对象,根据治疗方法将患者分为对照组和观察组,每组30例。对照组口服阿普唑仑片,0.4 mg/次,3次/d。观察组患者口服复方苁蓉益智胶囊,4粒/次,3次/d。两组均服用2周。观察两组患者的临床疗效和匹兹堡睡眠质量评分(PSQI),同时比较两组患者的焦虑自评量表(SAS)、抑郁自评量表(SDS)、Barthel指数(BI)。结果治疗后,观察组总有效率为86.70%,与对照组的90.00%相比,差异无统计学意义。治疗后,观察组的睡眠障碍评分、睡眠时间及日间功能评分均优于对照组(P<0.05)。治疗后,两组SAS、SDS评分均显著降低,观察组BI评分显著升高(P<0.05);治疗后,观察组SDS评分显著低于对照组,BI评分高于对照组(P<0.05)。结论复方苁蓉益智胶囊治疗帕金森病肝肾亏虚型失眠患者可有效改善睡眠质量,临床疗效显著。Objective To investigate the clinical effect of Compound Congrong Yizhi Capsules in treatment of insomnia of liver and kidney deficiency in Parkinson’s disease.Methods A total of 60 cases patients with Parkinson’s disease insomnia of liver and kidney deficiency syndrome in The Fourth Hospital of Changsha from January 2019 to June 2020 were selected as the research subjects.According to the treatment methods,the patients were divided into control group and observation group,with 30 cases in each group.Patients in the control group were po administered with Alprazolam Tablets,0.4 mg/time,three times daily.Patients in the observation group were po administered with Compound Congrong Yizhi Capsules,4 capsules/time,three times daily.Both groups were treated for 2 weeks.Clinical efficacy and PSQI score of two groups were observed,and the SAS,SDS,BI score and motor dysfunction score of two groups were compared.Results After treatment,the total effective rate of the observation group was 86.70%,compared with 90.00%of the control group,and the difference was not statistically significant.After treatment,the sleep disorder score,sleep time and daytime function score in observation group were better than those in control group(P<0.05).After treatment,SAS and SDS scores of two groups were significantly decreased,while BI score of the observation group was significantly increased(P<0.05).After treatment,SDS score was significantly lower than control group,BI score was higher than control group(P<0.05).Conclusion Compound Congrong Yizhi Capsules can effectively improve sleep quality in patients with insomnia of liver and kidney deficiency in Parkinson’s disease with significant clinical effect.

关 键 词：复方苁蓉益智胶囊 阿普唑仑 帕金森病 肝肾亏虚型 失眠 匹兹堡睡眠质量表评分 焦虑自评量表 抑郁自评量表 

分 类 号：R971[医药卫生—药品]